Argireline: needle‐free botox as analytical challenge,Chemistry & Biodiversity

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Argireline: needle‐free botox as analytical challenge
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-02-08 , DOI: 10.1002/cbdv.202000992
Alicja Kluczyk ₁ , Julita Ludwiczak ₁ , Maciej Modzel ₁ , Mariola Kuczer ₁ , Marek Cebrat ₁ , Monika Biernat ₁ , Remigiusz Bąchor ₁

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Argireline-containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect. Therefore, it is used as a safe needle-free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatography and tandem mass spectrometry (RP-HPLC-MS and MS/MS). The analysis revealed the presence of argireline and its oxidized form in several different cosmetics. The methionine residue in Argireline sequence was indicated as oxidation point according to neutral loss MS studies. The developed sample preparation strategy minimizes and monitors methionine oxidation, bringing to our attention the question of impact of ingredients on the stability of cosmetic product.

中文翻译：

Argireline：无针肉毒杆菌作为分析挑战

含 Argireline 的化妆品因其可减少面部皱纹而引起公众兴趣。Argireline 是一种肽，通过抑制神经肌肉接头中神经递质的释放，产生类似肉毒杆菌的作用。因此，它被用作肉毒杆菌毒素治疗的安全无针替代品。在这项工作中，我们通过应用反相液相色谱和串联质谱（RP-HPLC-MS 和 MS/MS）研究了美容霜和血清中 Argireline 的存在。分析表明，在几种不同的化妆品中存在阿吉瑞林及其氧化形式。根据中性丢失 MS 研究，Argireline 序列中的甲硫氨酸残基被指示为氧化点。开发的样品制备策略最大限度地减少和监测蛋氨酸氧化，

更新日期：2021-02-08

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