In this research, we have designed four isoniazid derivatives, i.e., isonicotinohydrazide (1-isonicotinoyl semicarbazide, 1-thiosemi isonicotinoyl carbazide, N '-(1, 3-dimethyl-1 h-pyrazole-5-carbonyl) isonicotino hydrazide, and N '-(1,2,3- 4-thiadiazole-carbonyl) isonicotinohydrazide. The docking and molecular dynamic have performed to them to study its interaction with Mycobacterium tuberculosis Enoyl-Acyl Carrier Protein Reductase (InhA). Based on this research, all of the compounds were predicted to have a stable interaction with Mycobacterium tuberculosis Enoyl-Acyl Carrier Protein Reductase (InhA) receptor so that they could be used as an anti-tuberculosis drug candidate

在这项研究中，我们设计了四种异烟肼衍生物，即异烟酰肼（1-异烟酰氨基脲，1-硫代异烟酰脲，N'-（1，3-二甲基-1 h-吡唑-5-羰基）异烟肼和N '-（1,2,3- 4-thiadiazole-羰基）异烟酰肼。对接和分子动力学已对其进行了研究，以研究其与结核分枝杆菌Enoyl-酰基载体蛋白还原酶（InhA）的相互作用。预计这些化合物与结核分枝杆菌烯酰基-酰基载体蛋白还原酶（InhA）受体具有稳定的相互作用，因此可以用作抗结核药物