The objective of this analysis was to determine possible interactions between lamotrigine (LTG) and coffee or cigarette use. As part of the statistical analysis of factors influencing LTG pharmacokinetics (PK) in the Equigen chronic dose study, we collected prospective data from enrolled patients on their use of coffee and cigarettes. Subjects were part of a crossover replication study of generic LTG products with rigorous blood sampling and were instructed to not change their typical consumption of these products for the duration of the study. A total of 35 subjects were enrolled, with 33 subjects having sufficient data for analysis. Higher consumption of coffee was associated with a significantly lower area under the curve (AUC) and maximum concentration (Cmax) of lamotrigine (LTG). Higher cigarette use did not result in a significant change in AUC or Cmax. Coffee, but not cigarette use, either induces LTG metabolism or inhibits LTG absorption.

中文翻译：

---

咖啡和吸烟与拉莫三嗪的相互作用

该分析的目的是确定拉莫三嗪 (LTG) 与咖啡或香烟使用之间可能的相互作用。作为 Equigen 慢性剂量研究中影响 LTG 药代动力学 (PK) 的因素的统计分析的一部分，我们收集了入选患者使用咖啡和香烟的前瞻性数据。受试者是具有严格血液采样的通用 LTG 产品交叉复制研究的一部分，并被指示在研究期间不要改变他们对这些产品的典型消费。总共招募了 35 名受试者，其中 33 名受试者有足够的数据进行分析。较高的咖啡消费量与显着较低的拉莫三嗪 (LTG) 曲线下面积 (AUC) 和最大浓度 (Cmax) 相关。较高的香烟使用量不会导致 AUC 或 Cmax 的显着变化。咖啡，而不是香烟的使用，要么诱导 LTG 代谢，要么抑制 LTG 吸收。