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A latent class analysis of cannabis use products in a general population sample of adolescents and their association with paranoia, hallucinations, cognitive disorganisation and grandiosity
Addictive Behaviors ( IF 3.7 ) Pub Date : 2021-01-21 , DOI: 10.1016/j.addbeh.2021.106837
Clare J. Mackie , Jack Wilson , Tom P. Freeman , Sam Craft , Thalia Escamilla De La Torre , Michael T. Lynskey

Adolescents have access to a wide range of cannabis products with patterns of use becoming increasingly diverse. This study aimed to identify subgroups of adolescents in the general population who use similar types of cannabis and their association with psychotic experiences. Data on cannabis use were obtained from 467 adolescents aged between 16 and 17 years. Latent class analysis (LCA) identified groups of adolescents based on the type of cannabis used in the past 12 months. Univariate analysis explored differences in socio-demographics, substance use and mental health symptoms between groups. Multivariate analysis examined associations between class membership and psychotic experiences controlling for frequency and amount of cannabis. Finally, we explored the association between motives for cannabis and class membership using multi-nominal logistic regression. LCA identified 3 classes of adolescents: (i) herbal only (47.9%); (ii) skunk only (20.8%) and (3) mixed use (31.3%). Relative to non-users, skunk only use was associated with a 2-fold increase in paranoia (OR = 2.45, 95% CI = 1.29–4.63), along with, sleep disturbance and anxiety. Monthly cannabis use and consuming 2 or more joints on one occasion was associated with a 2-fold increase in hallucinations (OR = 2.2; 95% CI = 1.0–4.8 and OR = 1.9; 95% CI = 1.2–3.2), but did not reach the Bonferroni corrected p-value. Expansion and conformity motives differentiated the mixed cannabis class from the herbal only class. The findings suggest that different subgroups of cannabis users exist in adolescence as defined by the type of cannabis consumed and are differentially related to psychotic experiences and motives for use.



中文翻译:

在青少年的总体人口样本中对大麻使用产品的潜在分类分析及其与妄想症,幻觉,认知障碍和夸大感的关联

青少年可以使用各种各样的大麻产品,使用方式也越来越多样化。这项研究旨在确定普通人群中使用相似类型大麻及其与精神病经历的关联的青少年亚组。有关大麻使用的数据来自16至17岁的467名青少年。潜在类别分析(LCA)根据过去12个月使用的大麻类型确定了青少年群体。单因素分析探讨了群体之间的社会人口统计学,物质使用和心理健康症状的差异。多变量分析检查了班级成员资格与控制大麻频率和数量的精神病经历之间的关联。最后,我们使用多项式逻辑回归研究了大麻动机与班级成员之间的关联。LCA确定了3类青少年:(i)仅使用草药(47.9%);(ii)仅臭鼬(20.8%)和(3)混合使用(31.3%)。相对于非使用者,仅使用臭鼬会导致偏执狂增加2倍(OR = 2.45,95%CI = 1.29–4.63),以及睡眠障碍和焦虑症。每月使用大麻并一次食用2个或更多关节会导致幻觉增加2倍(OR = 2.2; 95%CI = 1.0–4.8和OR = 1.9; 95%CI = 1.2–3.2),但确实如此未达到Bonferroni校正的p值。扩展和整合的动机使混合大麻类别与仅草药类别有所区别。

更新日期:2021-02-03
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