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The existence and linear stability of periodic solution for a free boundary problem modeling tumor growth with a periodic supply of external nutrients
Nonlinear Analysis: Real World Applications ( IF 2 ) Pub Date : 2021-01-22 , DOI: 10.1016/j.nonrwa.2021.103290
Wenhua He , Ruixiang Xing

We study a free boundary problem modeling tumor growth with a T-periodic supply Φ(t) of external nutrients. The model contains two parameters μ and σ˜. We first show that (i) zero radially symmetric solution is globally stable if and only if σ˜1T0TΦ(t)dt; (ii) If σ˜<1T0TΦ(t)dt, then there exists a unique radially symmetric positive solution σ(r,t),p(r,t),R(t) with period T and it is a global attractor of all positive radially symmetric solutions for all μ>0. These results are a perfect answer to open problems in Bai and Xu [Pac. J. Appl. Math. 2013(5), 217–223]. Then, considering non-radially symmetric perturbations, we prove that there exists a constant μ>0 such that σ(r,t),p(r,t),R(t) is linearly stable for μ<μ and linearly unstable for μ>μ.



中文翻译:

自由边界问题的周期解的存在性和线性稳定性,该问题模拟了具有周期性外部营养的肿瘤生长

我们研究了使用T周期供应模拟肿瘤生长的自由边界问题 ΦŤ外部营养。该模型包含两个参数μσ。我们首先证明(i)当且仅当零径向对称解是全局稳定的σ1个Ť0ŤΦŤdŤ; (ii)如果σ<1个Ť0ŤΦŤdŤ,则存在唯一的径向对称正解 σ[RŤp[RŤ[RŤ 随着时期 Ť 它是所有正径向对称解的全球吸引者 μ>0。这些结果是对Bai和Xu中未解决问题的完美答案。J.应用 数学。2013(5),217-223]。然后,考虑到非径向对称扰动,我们证明存在一个常数μ>0 这样 σ[RŤp[RŤ[RŤ 对...线性稳定 μ<μ 并且线性不稳定 μ>μ

更新日期:2021-01-22
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