It is known that the nucleus accumbens, orbitofrontal cortex and insula play a role in food-related reward processes. Although their interconnectedness would be an ideal topic for understanding food intake mechanisms, it nevertheless remains unclear especially in adolescent. Therefore, this study aims to investigate the effect of hunger on functional connectivity in healthy adolescents using task- and rest-based imaging. Fifteen participants underwent two MRI sessions, pre-lunch (hunger) and post-lunch (satiety), including food cue task and resting-state. During task- and rest-based imaging, functional connectivity was greater when hungry as opposed to satiated between the right posterior insula/nucleus accumbens, suggesting involvement of salient interoceptive stimuli signals. During task-based imaging, an increase was observed in functional connectivity when hungry as opposed to satiated between the medial and lateral orbitofrontal cortex which contributes to the perception of food deprivation as a frustration. A decrease was identified when hungry as opposed to satiated in functional connectivity in the right anterior orbitofrontal/accumbens and posterior insula/medial orbitofrontal cortices reflecting suppression of the affective and sensorial information. Conversely, functional connectivity was increased during aversive stimuli between the right medial orbitofrontal cortex and right posterior insula when hungry as opposed to satiated. This suggests that the value of valence could occur in the shift in connectivity between these two regions. In addition, during rest-based imaging, a left-sided lateralization was reported (accumbens/lateral orbitofrontal and accumbens/posterior insula) when hungry as opposed to satiated which may represent changes in internal state due to focus on the benefit of an upcoming meal.

众所周知，伏隔核，眶额皮层和岛绝缘在与食物有关的奖励过程中起作用。尽管它们的相互联系是理解食​​物摄入机制的理想话题，但仍不清楚，尤其是在青少年时期。因此，本研究旨在利用基于任务和休息的影像学来研究饥饿对健康青少年功能连接的影响。15名参与者进行了两次MRI训练，包括午餐前（饥饿）和午餐后（饱腹），包括食物提示任务和休息状态。在基于任务和休息的成像过程中，饥饿时的功能连通性更高，而不是右后绝缘体/伏隔核之间有饱足感，这暗示了明显的感受性刺激信号的参与。在基于任务的映像过程中，饥饿时观察到功能连通性增加，而眼眶额皮质内侧和外侧之间的饱足感则相反，这有助于将食物匮乏视为一种沮丧。饥饿时发现减少，而右前眶额/伏隔和后岛/中眶额皮质的功能连通性得到满足，反映出情感和感觉信息受到抑制。相反，在饥饿而不是饱食的情况下，在右侧内侧眶额皮层和右侧后岛之间的反感刺激期间，功能连接性增加。这表明化合价可能出现在这两个区域之间的连通性变化中。此外，在基于静止的成像中，