OBJECTIVE To investigate the association of endometrium preparation with perinatal outcomes. DESIGN Retrospective cohort study. SETTING University-affiliated fertility center. PATIENT(S) Twenty-one thousand six hundred and forty-eight women who underwent frozen single-blastocyst transfer from January 2013 to March 2019. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Cesarean delivery, preterm delivery (PTD), vaginal PTD, very preterm delivery (VPTD), postterm delivery, low birth weight (LBW), macrosomia, small for gestational age (SGA), large for gestational age (LGA), hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), premature rupture of membrane (PROM), placenta previa, and congenital abnormality. RESULT(S) Compared with natural cycles, hormone replacement cycles were associated with an increased risk of PTD, VPTD, cesarean delivery, macrosomia, PROM, and HDP. There was a trend toward an increased risk of vaginal PTD and LGA in hormone replacement cycles. Stimulated cycles were associated with an increased risk of postterm delivery and GDM. There was no statistically significant difference in the rate of SGA, placenta previa, or congenital abnormality among the three endometrium preparation methods. CONCLUSION(S) Hormone replacement cycles are associated with an increased risk of PTD, VPTD, cesarean delivery, LBW, macrosomia, PROM, and HDP. Stimulated cycles are associated with an increased risk of postterm delivery and GDM.

中文翻译：

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冷冻周期单囊胚移植妇女的子宫内膜准备和围产期结局

目的 探讨子宫内膜准备与围产期结局的关系。设计 回顾性队列研究。设置 大学附属生育中心。患者 21648 名从 2013 年 1 月至 2019 年 3 月接受冷冻单囊胚移植的女性。 干预 无。主要结局指标 剖宫产、早产 (PTD)、阴道 PTD、极早产 (VPTD)、早产、低出生体重 (LBW)、巨大儿、小于胎龄 (SGA)、大于胎龄 ( LGA)、妊娠高血压疾病 (HDP)、妊娠糖尿病 (GDM)、胎膜早破 (PROM)、前置胎盘和先天性异常。结果 与自然周期相比，激素替代周期与 PTD、VPTD、剖宫产、巨大儿、PROM 和 HDP。在激素替代周期中，阴道 PTD 和 LGA 的风险有增加的趋势。刺激周期与过期分娩和 GDM 的风险增加有关。三种子宫内膜制备方法的SGA、前置胎盘或先天性异常的发生率无统计学差异。结论 (S) 激素更换周期与 PTD、VPTD、剖宫产、LBW、巨大儿、PROM 和 HDP 的风险增加有关。受刺激的周期与过期分娩和 GDM 的风险增加有关。三种子宫内膜制备方法在SGA、前置胎盘或先天性异常发生率上无统计学差异。结论 (S) 激素更换周期与 PTD、VPTD、剖宫产、LBW、巨大儿、PROM 和 HDP 的风险增加有关。受刺激的周期与过期分娩和 GDM 的风险增加有关。三种子宫内膜制备方法的SGA、前置胎盘或先天性异常的发生率无统计学差异。结论 (S) 激素更换周期与 PTD、VPTD、剖宫产、LBW、巨大儿、PROM 和 HDP 的风险增加有关。受刺激的周期与过期分娩和 GDM 的风险增加有关。