当前位置：
X-MOL 学术
›
Comput. Struct. Biotechnol. J.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Review on circular RNAs and new insights into their roles in cancer
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-01-22 , DOI: 10.1016/j.csbj.2021.01.018 Xiaozhu Tang 1, 2 , Hongyan Ren 2 , Mengjie Guo 2 , Jinjun Qian 2 , Ye Yang 2 , Chunyan Gu 1, 2
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2021-01-22 , DOI: 10.1016/j.csbj.2021.01.018 Xiaozhu Tang 1, 2 , Hongyan Ren 2 , Mengjie Guo 2 , Jinjun Qian 2 , Ye Yang 2 , Chunyan Gu 1, 2
Affiliation
|
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA molecules derived from exonic or intronic sequences by precursor mRNA back-splicing. Unlike canonical linear RNAs, circRNAs form covalently closed, continuous stable loops without a 5′end cap and 3′end poly(A) tail, and therefore are resistant to exonuclease digestion. The majority of circRNAs are highly abundant, and conserved across different species with a tissue or developmental-stage-specific expression. circRNAs have been shown to play important roles as microRNA sponges, regulators of gene splicing and transcription, RNA-binding protein sponges and protein/peptide translators. Emerging evidence reveals that circRNAs function in various human diseases, particularly cancers, and may function as better predictive biomarkers and therapeutic targets for cancer treatment. In consideration of their potential clinical relevance, circRNAs have become a new research hotspot in the field of tumor pathology. In the present study, the current understanding of the biogenesis, characteristics, databases, research methods, biological functions subcellular distribution, epigenetic regulation, extracellular transport and degradation of circRNAs was discussed. In particular, the multiple databases and methods involved in circRNA research were first summarized, and the recent advances in determining the potential roles of circRNAs in tumor growth, migration and invasion, which render circRNAs better predictive biomarkers, were described. Furthermore, future perspectives for the clinical application of circRNAs in the management of patients with cancer were proposed, which could provide new insights into circRNAs in the future.
中文翻译：
环状RNA的回顾及其在癌症中的作用的新见解
环状 RNA (circRNA) 是一类非常有趣的保守单链 RNA 分子，通过前体 mRNA 反向剪接衍生自外显子或内含子序列。与典型的线性 RNA 不同，circRNA 形成共价闭合、连续稳定的环，没有 5' 端帽和 3' 端 Poly(A) 尾，因此能够抵抗核酸外切酶消化。大多数 circRNA 丰度很高，并且在不同物种中保守，具有组织或发育阶段特异性表达。 circRNA 已被证明作为 microRNA 海绵、基因剪接和转录调节器、RNA 结合蛋白海绵和蛋白质/肽翻译器发挥着重要作用。新的证据表明，circRNA 在各种人类疾病（特别是癌症）中发挥作用，并且可能作为癌症治疗的更好的预测生物标志物和治疗靶点。考虑到其潜在的临床意义，circRNA已成为肿瘤病理学领域的新研究热点。本研究对目前对circRNA的生物发生、特征、数据库、研究方法、生物学功能、亚细胞分布、表观遗传调控、细胞外运输和降解等方面的认识进行了讨论。特别是，首先总结了circRNA研究涉及的多个数据库和方法，并描述了确定circRNA在肿瘤生长、迁移和侵袭中潜在作用的最新进展，这使得circRNA成为更好的预测生物标志物。此外，还提出了 circRNA 在癌症患者管理中临床应用的未来前景，这可以为未来提供关于 circRNA 的新见解。
更新日期：2021-01-22
中文翻译：
环状RNA的回顾及其在癌症中的作用的新见解
环状 RNA (circRNA) 是一类非常有趣的保守单链 RNA 分子，通过前体 mRNA 反向剪接衍生自外显子或内含子序列。与典型的线性 RNA 不同，circRNA 形成共价闭合、连续稳定的环，没有 5' 端帽和 3' 端 Poly(A) 尾，因此能够抵抗核酸外切酶消化。大多数 circRNA 丰度很高，并且在不同物种中保守，具有组织或发育阶段特异性表达。 circRNA 已被证明作为 microRNA 海绵、基因剪接和转录调节器、RNA 结合蛋白海绵和蛋白质/肽翻译器发挥着重要作用。新的证据表明，circRNA 在各种人类疾病（特别是癌症）中发挥作用，并且可能作为癌症治疗的更好的预测生物标志物和治疗靶点。考虑到其潜在的临床意义，circRNA已成为肿瘤病理学领域的新研究热点。本研究对目前对circRNA的生物发生、特征、数据库、研究方法、生物学功能、亚细胞分布、表观遗传调控、细胞外运输和降解等方面的认识进行了讨论。特别是，首先总结了circRNA研究涉及的多个数据库和方法，并描述了确定circRNA在肿瘤生长、迁移和侵袭中潜在作用的最新进展，这使得circRNA成为更好的预测生物标志物。此外，还提出了 circRNA 在癌症患者管理中临床应用的未来前景，这可以为未来提供关于 circRNA 的新见解。
京公网安备 11010802027423号