⁴⁴Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, ⁴⁴Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of ⁴⁴Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with ¹⁸F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of ⁴⁴Sc and ¹⁸F. Due to prompt gamma emission of ⁴⁴Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of ⁴⁴Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.

⁴⁴ Sc 是一种越来越多研究的正电子发射器，用于正电子发射断层扫描 (PET) 成像。然而，⁴⁴ Sc 是一种非纯正电子发射器，因为在衰变过程中会同时发射瞬发光子。本研究调查了⁴⁴ Sc 的重合能谱及其对临床前和临床 PET 系统与¹⁸ F相比的 PET 量化的影响。重合事件的原始数据揭示了比较⁴⁴ Sc 和¹⁸ F的光子能量分布的特征差异。由于⁴⁴ Sc 的快速伽马发射，PET 系统的活性恢复被低估。然而，临床 PET 成像⁴⁴通过使用单一的、恒定的校正因子，具有可接受的定量准确度的 Sc 似乎是可行的。