Rat-inbred strains are essential as scientific tools. We have analyzed the publicly available genome sequences of 40 rat-inbred strains and provide an overview of sequence variations leading to amino acid changes in protein-coding genes, premature STOP codons or loss of STOP codons, and short in-frame insertions and deletions of all protein-coding genes across all these inbred lines. We provide an overview of the predicted impact on protein function of all these affected proteins in the database, by comparing their sequence with the sequences of the rat reference strain BN/SsNHsdMcwi. We also investigate the flaws of the protein-coding sequences of this reference strain itself, by comparing them with a consensus genome. These data can be retrieved via a searchable website (Ratpost.be) and allow a global, better interpretation of genetic background effects and a source of naturally defective alleles in these 40 sequenced classical and high-priority rat-inbred strains.

大鼠近交品系作为科学工具是必不可少的。我们分析了 40 个大鼠近交品系的公开可用基因组序列，并概述了导致蛋白质编码基因氨基酸变化、终止密码子过早或终止密码子丢失以及框内短插入和缺失的序列变异。所有这些自交系中的所有蛋白质编码基因。我们通过将它们的序列与大鼠参考菌株 BN/SsNHsdMcwi 的序列进行比较，概述了数据库中所有这些受影响蛋白质对蛋白质功能的预测影响。我们还通过将它们与共有基因组进行比较来研究该参考菌株本身的蛋白质编码序列的缺陷。这些数据可以通过一个可搜索的网站 (Ratpost.be) 进行检索，并允许全球、