Quercetin, one of the bioactive flavonoid, prevents the proliferation of various cancer cells and has anti-cancer effects. In this study, we have developed a novel functionalized Fe₃O₄ nanoparticle by chitosan for quercetin delivery. The magnetic nanoparticles were physicochemically characterized by FT-IR, XRD and FE-SEM. The functionalized Fe₃O₄ nanoparticle was obtained in spherical shape with diameter of 50 nm. Quercetin was efficiently loaded into the prepared magnetic nanoparticles and content of it was determined by the Folin–Ciocalteu assay, finding a 117.9 mg of quercetin/ of magnetic nanoparticles. The cytotoxic activity of prepared MNPs was studied by MTT assay. Quercetin loaded MNPs exhibited greater toxicity against MCF-7 cells compared to quercetin free magnetic nanoparticles. Toxicity effect of quercetin loaded MNPs against cancerous cells make them as promising candidate for further study in cancer treatment.

槲皮素是一种生物活性类黄酮，可防止各种癌细胞的增殖并具有抗癌作用。在这项研究中，我们已经开发了一种新型的壳聚糖功能化的Fe ₃ O ₄纳米颗粒，用于槲皮素的递送。通过FT-IR，XRD和FE-SEM对磁性纳米粒子进行了物理化学表征。功能化的Fe ₃ O ₄获得直径为50nm的球形纳米颗粒。将槲皮素有效地装载到制备的磁性纳米颗粒中，并通过Folin–Ciocalteu分析测定含量，结果发现槲皮素/磁性纳米颗粒含量为117.9 mg。通过MTT测定研究了制备的MNP的细胞毒性活性。与不含槲皮素的磁性纳米颗粒相比，装有槲皮素的MNP对MCF-7细胞表现出更大的毒性。槲皮素负载的MNP对癌细胞的毒性作用使其成为有望在癌症治疗中进一步研究的候选药物。