Gold nanorod (AuNR) nanocomposite hydrogels have attracted increasing attention due to the photothermal effect of AuNRs. However, a facile strategy that avoids multi-step surface modification for synthesis of AuNR crosslinkers is still a critical challenge. Here, AuNRs crosslinking PNIPAM hydrogels were prepared by polymerization of NIPAM with N , N ′-bis(acryloyl)cystamine (BACA)-modified AuNRs as crosslinkers. BACA contains a disulfide bond in the structure. Dynamic and reversible Au-thiolate bonding was formed by directly mixing AuNRs and BACA to facilely prepare AuNR crosslinkers before hydrogel formation. The addition of AuNRs gives hydrogels their photothermal effect and remarkable mechanical behaviors. Hydrogels could repeatedly adhere to the surface of pigskin, metal, plastic, and glass with a relatively stable adhesion. The damaged hydrogels heal within 2 min with near-infrared (NIR) laser (808 nm, 300 mW∙cm −2 ) irradiation. This work provides a line of thinking for improvement of PNIPAM hydrogels, making them promising for further applications in biomedicine.

中文翻译：

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金纳米棒通过动态金-硫醇盐相互作用交联 PNIPAM 水凝胶，具有可拉伸、粘合、自修复和光热特性

由于AuNRs的光热效应，金纳米棒（AuNR）纳米复合水凝胶引起了越来越多的关注。然而，在合成 AuNR 交联剂时避免多步表面改性的简便策略仍然是一个关键挑战。在这里，AuNRs 交联 PNIPAM 水凝胶是通过 NIPAM 与 N , N '-双（丙烯酰基）胱胺（BACA）-修饰的 AuNRs 作为交联剂聚合制备的。BACA 在结构中包含一个二硫键。通过直接混合 AuNRs 和 BACA 以在水凝胶形成之前轻松制备 AuNR 交联剂，形成动态和可逆的 Au-硫醇键。AuNRs 的加入使水凝胶具有光热效应和显着的机械性能。水凝胶可以反复粘附在猪皮、金属、塑料和玻璃的表面，并具有相对稳定的粘附力。受损的水凝胶在近红外 (NIR) 激光 (808 nm, 300 mW∙cm -2 ) 照射下在 2 分钟内愈合。这项工作为改进 PNIPAM 水凝胶提供了思路，使其有望在生物医学中进一步应用。