Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the anxiolytic-like effects of Urena lobata L. (MEUL) methanolic extract in different behavioral paradigms in Swiss albino mice. For this, after an oral acute toxicity study, adult male mice were treated with MEUL (250 and 500 mg/kg, p.o.) and/or diazepam (2 mg/kg, i.p.), and subjected to a number of behavioral studies. In the open-field test, the number of square field cross, grooming, and rearing, was counted, while in the light/dark and swing test, the time spent in the dark portion and number of swings was calculated, respectively. Additionally, the phytochemical analysis was also done. Results reveal that the MEUL possesses alkaloids, glycosides, flavonoids, phenols, saponins, terpenes (including triterpenes), gums, and reducing sugars. MEUL showed a significant (p < 0.05) anxiolytic-like effect in experimental animals, where it’s dose-dependently modulated the test parameters in an open-field test. The MEUL also increased the light residence time and the number of swings in a dose-dependent manner. A dose of 500 mg/kg of MEUL caused the highest calming effect when combined with the experimental animals’ diazepam group. Taken together, findings expand an understanding of the impact of U. lobata on the central nervous system and show that this plant may be useful for the treatment of disorders associated with anxiety.

中文翻译：

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Anxiolytic-样的效果地桃花在（L.）瑞士小白鼠

焦虑症是普遍的心理问题，也与抑郁症状有关。这项研究旨在调查在瑞士的白化病小鼠不同行为范式中的乌雷娜甲醇提取物的抗焦虑样作用。为此，在进行口服急性毒性研究后，成年雄性小鼠接受了MEUL（250和500 mg / kg，口服）和/或地西epa（2 mg / kg，腹膜内）治疗，并进行了许多行为研究。在开场测试中，计算了方场交叉，修饰和饲养的次数，而在明/暗和挥杆测试中，分别计算了在暗部花费的时间和挥杆次数。另外，还进行了植物化学分析。结果表明，MEUL具有生物碱，糖苷，类黄酮，酚，皂苷，萜烯（包括三萜烯），树胶和还原糖。MEUL在实验动物中显示出显着（p <0.05）的抗焦虑作用，在露天试验中，MEUL剂量依赖性地调节了测试参数。MEUL还以剂量依赖性方式增加了光停留时间和摆动次数。当与实验动物的地西epa组合用时，以500 mg / kg的MEUL剂量引起最高的镇静作用。综上所述，研究结果扩大了对叶状弓形虫对中枢神经系统影响的理解，并表明该植物可能对治疗与焦虑症有关的疾病有用。MEUL还以剂量依赖性方式增加了光停留时间和摆动次数。当与实验动物的地西epa组合用时，以500 mg / kg的MEUL剂量引起最高的镇静作用。综上所述，研究结果扩大了对叶状弓形虫对中枢神经系统影响的理解，并表明该植物可能对治疗与焦虑症有关的疾病有用。MEUL还以剂量依赖性方式增加了光停留时间和摆动次数。当与实验动物的地西epa组合用时，以500 mg / kg的MEUL剂量引起最高的镇静作用。综上所述，研究结果扩大了对叶状弓形虫对中枢神经系统影响的理解，并表明该植物可能对治疗与焦虑症有关的疾病有用。