Nanosystems as curative platforms for allergic disorder management,Journal of Materials Chemistry B

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Nanosystems as curative platforms for allergic disorder management
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-31 , DOI: 10.1039/d0tb02590a
Peng-Sheng Fan _{1,

2,

3,

4} , Meng-Jie Sun _{1,

2,

3,

4} , Di Qin _{1,

2,

3,

4} , Cong-Shan Yuan _{1,

2,

3,

4} , Xi-Guang Chen _{1,

2,

3,

4} , Ya Liu _{1,

2,

3,

4}

Affiliation

Allergy, IgE-mediated inflammatory disorders including allergic rhinitis, asthma, and conjunctivitis, affects billions of people worldwide. Conventional means of allergy management include allergen avoidance, pharmacotherapy, and emerging therapies. Among them, chemotherapeutant intake via oral, intravenous, and intranasal routes is always the most common mean. Although current pharmacotherapy exhibit splendid anti-allergic effects, short in situ retention, low bioavailability, and systemic side effects are inevitable. Nowadays, nanoplatforms have provided alternative therapeutic options to obviate the existing weakness via enhancing the solubility of hydrophobic therapeutic agents, achieving in situ drug accumulation, exhibiting controlled and long-time drug release at lesion areas, and providing multi-functional therapeutic strategies. Herein, we highlight the clinical therapeutic strategies and deal with characteristics of the nanoplatform design in allergy interventions via intratracheal, gastrointestinal, intravenous, and ocular paths. The promising therapeutic utilization in a variety of allergic disorders is discussed, and recent perspectives on the feasible advances of nanoplatforms in allergy management are also exploited.

中文翻译：

纳米系统作为过敏性疾病管理的治疗平台

过敏，IgE介导的炎症性疾病，包括变应性鼻炎，哮喘和结膜炎，影响着全球数十亿人。常规的过敏管理方法包括避免过敏原，药物治疗和新兴疗法。其中，通过口服，静脉内和鼻内途径摄入化学疗法一直是最常见的方法。尽管当前的药物治疗表现出出色的抗过敏作用，但不可避免的是原位保留时间短，生物利用度低和全身性副作用。如今，纳米平台已经提供了替代性治疗选择，以通过增强疏水性治疗剂的溶解性来消除现有的弱点，从而实现就地治疗。药物蓄积，在病变区域表现出受控的和长期的药物释放，并提供多功能治疗策略。在本文中，我们重点介绍了临床治疗策略，并通过气管内，胃肠道，静脉内和眼部路径在过敏性干预措施中处理了纳米平台设计的特征。讨论了在各种变态反应性疾病中有希望的治疗应用，并且还探讨了纳米平台在变态反应管理中的可行进展的最新观点。

更新日期：2021-01-21

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