Growth and inhibition of monohydrate sodium urate banded spherulites,CrystEngComm

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Growth and inhibition of monohydrate sodium urate banded spherulites
CrystEngComm ( IF 2.6 ) Pub Date : 2020-12-22 , DOI: 10.1039/d0ce01378a
Yao Zhou _{1,

2,

3,

4,

5} , Xiaowei Feng _{1,

2,

3,

4,

5} , Ting Wang _{6,

7,

8,

9,

10} , Yang Tian _{1,

2,

3,

4,

5} , Xiaoyan Cui _{1,

2,

3,

4,

5}

Affiliation

Gout is a chronic arthritis which arises from the abnormal crystalline deposition of monosodium urate (MSU). Banded spherulites of MSU were widely observed in gout pathological slices (E. Pascual, L. Addadi, M. Andrés and F. Sivera, Nat. Rev. Rheumatol., 2015, 11, 725) with limited understanding. MSU spherulites were obtained by evaporation growth showing banded morphologies induced from both twisting and rhythmic deposition. Taking the MSU spherulite as a facile model for the analysis of inhibitors for MSU crystals, the inhibition of MSU by three tailor-made additives, 1,3-dimethyluric acid (DMUA), 1-methyluric acid (MUA), and xanthine, resulted in MSU spherulites with different morphologies. The theoretical calculation has confirmed the distinct interaction of the different additives on the MSU crystalline faces.

中文翻译：

一水合尿酸钠带状球晶的生长和抑制

痛风是一种慢性关节炎，由尿酸单钠盐（MSU）的异常晶体沉积引起。在痛风病理切片中广泛观察到MSU的带状球晶（E. Pascual，L.Addadi，M.Andrés和F.Sivera，Nat.Rev.Rhematomal。，2015，11，725）。通过蒸发生长获得MSU球晶，其显示出扭曲和有节奏的沉积所诱导的带状形态。以MSU球晶作为分析MSU晶体抑制剂的简便模型，可以得到三种定制添加剂，即1,3-二甲基尿酸（DMUA），1-甲基尿酸（MUA）和黄嘌呤对MSU的抑制作用在不同形态的MSU球晶中。理论计算已证实MSU晶面上不同添加剂的独特相互作用。

更新日期：2021-01-21

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