Genetically encoding ε-N-benzoyllysine in proteins,Chemical Communications

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Genetically encoding ε-N-benzoyllysine in proteins
Chemical Communications ( IF 4.3 ) Pub Date : 2021-1-8 , DOI: 10.1039/d0cc07954e
Yanli Ji ₁ , Conghui Ren , Hui Miao , Zhili Pang , Ruotong Xiao , Xiaochen Yang , Weimin Xuan

Affiliation

Lysine ε-N-benzoylation is a recently identified PTM occurring on histone proteins, and herein we genetically encoded ε-N-benzoyl-lysine (BzK) into recombinant proteins in E. coli and mammalian cells, and applied it for the modification of histone proteins and the analysis of sirtuin debenzoylase activity.

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