Pediatric-onset multiple sclerosis (MS) affects 2%– 10% of all individuals with MS and is known to be associated with greater magnetic resonance imaging (MRI) lesion burden,1 but a lengthier time to progression to irreversible disability than in the adult MS population.2 Importantly, numerous studies have highlighted high levels of depression and fatigue,3–5 and high rates of cognitive impairment in this population, with one early study suggesting cognitive deterioration in almost three-fourths of children with MS in the years after disease onset.6,7 However, the realworld burden of these cognitive and psychiatric outcomes in youth with MS remains unknown: Do high rates of depressive symptomatology and cognitive impairment recorded in clinical settings result in higher utilization of healthcare services by this group, and is there a higher likelihood that these adolescents will suffer from worse school-related outcomes?

中文翻译：

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儿科多发性硬化症的真实结果：精神病合并症和学校表现

小儿多发性硬化症 (MS) 影响所有 MS 患者的 2% 至 10%，并且已知与更大的磁共振成像 (MRI) 病变负担相关 1，但进展为不可逆残疾的时间比成人更长MS 人群。2 重要的是，许多研究都强调了这一人群的高度抑郁和疲劳，3-5 以及高认知障碍发生率，一项早期研究表明，在之后的几年中，几乎四分之三的 MS 儿童认知能力下降。 6,7 然而，MS 青年的这些认知和精神结果的真实世界负担仍然未知：临床环境中记录的高抑郁症状和认知障碍率是否会导致该群体对医疗保健服务的更高利用，这些青少年遭受更糟糕的学校相关结果的可能性是否更高？