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Reducing-Agent-Free Convergent Synthesis of Hydroxyimino-Decorated Tetracyclic Fused Cinnolines via RhIII-Catalyzed Annulation Using Nitroolefins
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.joc.0c02729 Pidiyara Karishma 1 , Chikkagundagal K Mahesha 1 , Sanjay K Mandal 2 , Rajeev Sakhuja 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-01-21 , DOI: 10.1021/acs.joc.0c02729 Pidiyara Karishma 1 , Chikkagundagal K Mahesha 1 , Sanjay K Mandal 2 , Rajeev Sakhuja 1
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A mild Rh-catalyzed method was developed for the synthesis of hydroxyimino functionalized indazolo[1,2-a]cinnolines and phthalazino[2,3-a]cinnolines by reductive [4 + 2] annulation between 1-arylindazolones and 2-aryl-2,3-dihydrophthalazine-1,4-diones with varied nitroolefins. The targeted oxime decorated tetracyclic fused cinnolines were synthesized via sequential C–H activation/olefin insertion/reduction under reducing-agent-free conditions.
中文翻译：
还原剂-免费收敛羟基亚装饰四环融合噌的通过合成的Rh三催化的环使用Nitroolefins
开发了一种温和的Rh催化方法，通过还原1-芳基吲唑酮和2-芳基-[4 + 2]环合反应，合成羟基亚氨基官能化的吲唑并[1,2- a ] cinnolines和邻苯并[2,3- a ] cinnolines。 2,3-二氢酞嗪-1,4-二酮与各种硝基烯烃。在无还原剂的条件下，通过连续的C–H活化/烯烃插入/还原反应，合成了目标肟肟修饰的四环稠合肉桂醛。
更新日期：2021-02-05
中文翻译：
还原剂-免费收敛羟基亚装饰四环融合噌的通过合成的Rh三催化的环使用Nitroolefins
开发了一种温和的Rh催化方法，通过还原1-芳基吲唑酮和2-芳基-[4 + 2]环合反应，合成羟基亚氨基官能化的吲唑并[1,2- a ] cinnolines和邻苯并[2,3- a ] cinnolines。 2,3-二氢酞嗪-1,4-二酮与各种硝基烯烃。在无还原剂的条件下，通过连续的C–H活化/烯烃插入/还原反应，合成了目标肟肟修饰的四环稠合肉桂醛。
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