In persistent pulmonary hypertension of the newborn (PPHN), the ratio of pulmonary vascular resistance to systemic vascular resistance is increased. Extrapulmonary shunts (patent ductus arteriosus and patent foramen value) allow for right-to-left shunting and hypoxaemia. Systemic hypotension can occur in newborns with PPHN due to variety of reasons, such as enhanced peripheral vasodilation, impaired left ventricular function and decreased preload. Systemic hypotension can lead to end organ injury from poor perfusion and hypoxaemia in the newborn with PPHN. Thus, it must be managed swiftly. However, not all newborns with PPHN and systemic hypotension can be managed the same way. Individualised approach based on physiology and echocardiographic findings are necessary to improve perfusion to essential organs. Here we present a review of the physiology and mechanisms of systemic hypotension in PPHN, which can then guide treatment. No data are available. A review article with no data.

中文翻译：

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新生儿持续性肺动脉高压足月儿全身性低血压的治疗：图文并茂的综述


在新生儿持续性肺动脉高压（PPHN）中，肺血管阻力与全身血管阻力的比率增加。肺外分流（动脉导管未闭和孔未闭值）可实现从右向左分流和低氧血症。由于多种原因，如外周血管舒张增强、左心室功能受损和前负荷降低，患有 PPHN 的新生儿可能会出现全身性低血压。全身性低血压可导致 PPHN 新生儿因灌注不良和低氧血症而导致终末器官损伤。因此，必须迅速对其进行管理。然而，并非所有患有 PPHN 和全身性低血压的新生儿都能以同样的方式进行治疗。基于生理学和超声心动图结果的个体化方法对于改善重要器官的灌注是必要的。在这里，我们对 PPHN 全身性低血压的生理学和机制进行综述，以指导治疗。无可用数据。一篇没有数据的评论文章。