Network pharmacology analysis has shown that Qu Feng Xuan Bi Formula (QFXBF) is a traditional Chinese herbal medicine used to treat bronchial asthma, with demonstrated remarkable effects; however, its effects on airway inflammation and bronchial asthma alleviation remain unclear. This study aimed to explore the underlying mechanism of QFXBF by assessing toll-like receptor-9 (TLR-9) and the downstream MAPK signaling pathway as well as the immune modulation of the Th1/Th2 balance. The results showed that the aqueous extract of QFXBF increased TLR-9 expression, regulated the downstream genes AP-1, JNK, and ERK1/2, and reduced serum IL-5 levels in the high-dose QFXBF group; meanwhile, following QFXBF treatment, IFN-γ and TNF-α levels were increased, indicating that the Th1/Th2 immune balance was reversed as predicted. These findings provide a mechanism underlying QFXBF’s effects, which significantly improves the treatment and management of patients with bronchial asthma and profoundly impacts medical information processing.

中文翻译：

---

祛风宣痹方通过改善哮喘模型中的支气管免疫平衡来减轻气道炎症并指导临床治疗

网络药理分析表明，祛风宣痹方（QFXBF）是一种用于治疗支气管哮喘的中草药，具有明显的疗效。然而，其对气道炎症和减轻支气管哮喘的作用尚不清楚。这项研究旨在通过评估收费样受体9（TLR-9）和下游MAPK信号通路以及Th1 / Th2平衡的免疫调节来探索QFXBF的潜在机制。结果表明：高剂量QFXBF组水提液能提高TLR-9表达，调节下游基因AP-1，JNK和ERK1 / 2，降低血清IL-5水平。同时，经QFXBF治疗后，IFN- γ和TNF - α免疫球蛋白水平升高，表明Th1 / Th2免疫平衡如预期的那样逆转。这些发现为QFXBF的作用提供了潜在的机制，该机制显着改善了支气管哮喘患者的治疗和管理，并深刻影响了医疗信息的处理。