Acinetobacter baumannii is a Gram-negative pathogen that has emerged as one of the most troublesome pathogens for health care institutions globally. Bacterial quorum sensing (QS) is a process of cell-to-cell communication that relies on the production, secretion and detection of autoinducer (AI) signals to share information about cell density and regulate gene expression accordingly. In this study, we performed a comprehensive set of experiments show that deletion of quorum sensing genes showed differences in growth characteristics, morphology, biofilm formation and virulence, and increased susceptibility to some antimicrobials and exhibited motility defects. RNA-seq analysis indicated that genes involved in various aspects of energy production and conversion, Valine, leucine and isoleucine degradation and lipid transport and metabolism showed different expression.

中文翻译：

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abaI / abaR群体感应系统影响鲍曼不动杆菌的致病性

鲍曼不动杆菌是革兰氏阴性病原体，已成为全球卫生保健机构最麻烦的病原体之一。细菌群体感应（QS）是细胞间通信的过程，其依赖于自动诱导剂（AI）信号的产生，分泌和检测来共享有关细胞密度的信息并相应地调节基因表达。在这项研究中，我们进行了一套全面的实验，结果表明，群体感应基因的缺失显示出生长特征，形态，生物膜形成和毒力的差异，并且对某些抗菌剂的敏感性增加，并表现出运动性缺陷。RNA-seq分析表明，与能量产生和转化，缬氨酸，