We sequenced the genome of Streptomyces sp. JB150, isolated from a unique site of the Thar desert in India. Genome mining of the JB150 genome revealed the presence of many interesting secondary metabolic biosynthetic gene clusters (BGCs). The encoded parvome of JB150 includes non-ribosomal peptides, polyketides including β-lactone, butyrolactone, ectoine, lantipeptides, lasso peptides, melanin, resorcinol, siderophores, terpenoids, thiopeptides, and other types of hybrid compounds. Among them, ~30% BGCs displayed a high degree of novelty. The genome of JB150 was enriched for a large assortment of specialized genes coding for the production of many interesting biomolecules comprising compatible solutes, multiple stressresponse regulators, transport proteins, protein secretion systems, signaling molecules, chaperones and storage reserves, etc. The presence of diverse members of CAZymes enzyme families, high numbers of riboflavin, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), trehalose and aromatic compounds synthesis genes, putative orthologues to several of the classical fatty acid synthesis components, prototrophy for many essential amino acids exhibit metabolic versatility of JB150 to inhabit in the extreme desert environment. Besides, the genome of JB150 was observed to specifically encode thiazole-oxazole-modified thiazolemicrocin (TOMM) and ectoine. The comparison of the complete genomes of Streptomyces sp. JB150 and seven other actinomycete strains belonging to different desert ecosystems unveiled the presence of many previously undetected, distinctive, biological, and genomic signatures. We propose that these genetic traits endowed by these strains are essential for their adaptation in the highly underprivileged, extreme ecosystem of the Thar desert to cope with multiple abiotic stressors, oligotrophic nutrient conditions and to produce a huge repertoire of diverse secondary metabolites.

中文翻译：

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比较的全基因组分析的塔尔沙漠株链霉菌。JB150提供了对编码的Parvome的深刻见解以及对沙漠深水系统的适应性

我们对链霉菌的基因组进行了测序。JB150，与印度塔尔沙漠的独特地点隔离。JB150基因组的基因组挖掘揭示了许多有趣的次级代谢生物合成基因簇（BGC）的存在。JB150的编码Parvome包括非核糖体肽，包括β-内酯，丁内酯，ectoine，lantipeptides，套索肽，黑色素，间苯二酚，铁载体，萜类，硫代肽和其他类型的杂合化合物的聚酮化合物。其中，约30％的BGC具有很高的新颖性。JB150的基因组丰富了各种各样的专门基因，这些基因编码产生许多有趣的生物分子，这些生物分子包括相容性溶质，多种应激反应调节剂，转运蛋白，蛋白质分泌系统，信号分子，分子伴侣和储存储备等。CAZymes酶家族的不同成员，核黄素，黄素单核苷酸（FMN）和黄素腺嘌呤二核苷酸（FAD），海藻糖和芳香族化合物合成基因的数量众多，某些经典脂肪酸合成成分的直向同源物，许多的原营养必需氨基酸具有JB150的代谢多功能性，可在极端沙漠环境中栖息。此外，观察到JB150的基因组特异性编码噻唑-恶唑修饰的噻唑微素（TOMM）和外皮素。链霉菌完整基因组的比较。JB150和其他七个属于不同沙漠生态系统的放线菌菌株揭示了许多以前未被发现，独特，生物学和基因组特征的存在。