Optical coherence tomography (OCT) is a growing imaging technique for real-time early diagnosis of digestive system diseases. As with other well-established medical imaging modalities, OCT requires validated imaging performance and standardized test methods for performance assessment. A major limitation in the development and testing of new imaging technologies is the lack of models for simultaneous clinical procedure emulation and characterization of healthy and diseased tissues. Currently, the former can be tested in large animal models and the latter can be tested in small animal disease models or excised human biopsy samples. In this study, a 23 cm by 23 cm optical phantom was developed to mimic the thickness and near-infrared optical properties of each anatomical layer of a human colon, as well as the surface topography of colorectal polyps and visual appearance compatible with white light endoscopy.

中文翻译：

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结肠镜影与癌症病变的光学相干断层扫描内窥镜表征

光学相干断层扫描（OCT）是一种用于实时早期诊断消化系统疾病的成像技术。与其他完善的医学成像模式一样，OCT需要经过验证的成像性能和标准化的测试方法来进行性能评估。新成像技术的开发和测试的主要局限性在于缺乏同时进行临床过程仿真和表征健康和患病组织的模型。当前，前者可以在大型动物模型中进行测试，而后者可以在小型动物疾病模型或切除的人类活检样品中进行测试。在这项研究中，开发了一种23 cm x 23 cm的光学体模，以模拟人类结肠每个解剖层的厚度和近红外光学特性，