Frontiers in Cell and Developmental Biology ( IF 4.6 ) Pub Date : 2020-12-16 , DOI: 10.3389/fcell.2020.571676 Siddhartha Kumar Mishra , Yun Soo Bae , Yong-Moon Lee , Jae-Sung Kim , Seung Hyun Oh , Hwan Mook Kim
Chemosensitization of cancer cells with small molecules may improve the therapeutic index of antitumoral agents by making tumor cells sensitive to the drug regimen and thus overcome the treatment resistance and side effects of single therapy. Cell membrane lipid rafts are known to transduce various signaling events in cell proliferation. Sensitizing cancer cells may cause modulation of membrane lipid rafts which may potentially be used in improving anticancer drug response. Cedrol, a natural sesquiterpene alcohol, was used to treat human leukemia K562 and colon cancer HT-29 cell lines, and effects were observed. Cedrol decreased the cell viability by inducing apoptosis in both cell lines by activation of pro-apoptosis protein BID and inhibition of anti-apoptosis proteins Bcl-X
中文翻译:
倍半萜烯醇雪松醇对人癌细胞具有化学敏感性,并通过使血浆膜脂筏不稳定来抑制细胞增殖。
用小分子对癌细胞进行化学增敏可以通过使肿瘤细胞对药物方案敏感来改善抗肿瘤剂的治疗指数,从而克服单一疗法的治疗抗性和副作用。已知细胞膜脂质筏可转导细胞增殖中的各种信号事件。致敏的癌细胞可能引起膜脂筏的调节,其可能潜在地用于改善抗癌药物反应。天然倍半萜烯醇Cedrol被用于治疗人白血病K562和结肠癌HT-29细胞系,并观察到效果。Cedrol通过激活促凋亡蛋白BID和抑制抗凋亡蛋白Bcl-X诱导两种细胞系的凋亡来降低细胞活力