Introduction: Intra-arterial chemotherapy (IAC) is useful for eye preservation in advanced retinoblastoma (Rb). Intra-vitreal chemotherapy (IvitC) is the latest treatment for vitreous seeds. Methods: The present study is a retrospective assessment of 100 eyes, treated with primary or secondary IAC alone or with IvitC. We evaluated demographic and clinical variables, eye salvage, associated adverse events, and patient survival. Data were analyzed using descriptive statistics. Kaplan-Meier survival curves and Cox hazard ratios were utilized to assess the effect of demographic and clinical variables over eye salvage. Results: Bilateral Rb was observed in 61% of patients, and 57% of eyes received secondary treatment. Forty eyes needed intra-arterial plus IvitC and 62 presented advanced disease (group D and E). Three- and 5-year ocular survival probabilities were 75 and 68%. We found a higher risk in group D and E eyes and those requiring 2 or more routes for ophthalmic artery catheterization. Patients coming from other countries also showed increased risk. Using primary or secondary treatment, or IvitC, did not affect this risk. Overall rates of survival and eye salvages were 98.8 and 73%, and we had a 100% catheterization success and none ophthalmic arterial occlusions. Conclusions: In an upper middle-income country such as Colombia, a specialized institution counting with therapeutic alternatives and a multidisciplinary team can reach rates of patient survival and eye salvage similar to those of high-income countries.
Ocul Oncol Pathol

中文翻译：

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通过动脉内和玻璃体内化疗挽救视网膜母细胞瘤患者的眼睛：哥伦比亚 8 年单机构经验


简介：动脉内化疗 (IAC) 对于晚期视网膜母细胞瘤 (Rb) 的眼睛保存很有用。玻璃体内化疗（IvitC）是玻璃体种子的最新治疗方法。方法：本研究对 100 只眼睛进行了回顾性评估，这些眼睛分别接受初级或次级 IAC 单独治疗或联合 IvitC 治疗。我们评估了人口统计学和临床​​变量、眼睛挽救、相关不良事件和患者生存率。使用描述性统计分析数据。利用 Kaplan-Meier 生存曲线和 Cox 风险比来评估人口统计和临床变量对眼睛挽救的影响。结果： 61%的患者观察到双侧Rb，57%的眼睛接受了二级治疗。 40 只眼睛需要动脉内加 IvitC，其中 62 只眼睛出现晚期疾病（D 组和 E 组）。三年和五年的眼部存活率分别为 75% 和 68%。我们发现 D 组和 E 组眼睛以及需要 2 条或更多路径进行眼动脉导管插入术的眼睛风险较高。来自其他国家的患者也表现出较高的风险。使用一级或二级治疗或 IvitC 不会影响这种风险。总体存活率和眼睛挽救率分别为 98.8% 和 73%，导管插入成功率 100%，没有出现眼动脉闭塞。结论：在哥伦比亚等中高收入国家，一个专门研究治疗方案的机构和一个多学科团队可以达到与高收入国家相似的患者生存率和眼睛挽救率。
 眼肿瘤病理