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Strengthening the Reporting of Nutritional Genomics Research to Inform Knowledge Translation in Personalized Nutrition
Lifestyle Genomics ( IF 2.0 ) Pub Date : 2021-01-21 , DOI: 10.1159/000512544
Justine R Horne 1
Affiliation  

The ultimate goal of researching nutrigenetic interactions is to be able to provide individuals with genetically-tailored nutrition advice (when evidence is sufficient) in an effort to optimize health outcomes. Accordingly, original research often discusses the potential for the results to inform genetically-tailored nutrition advice. Despite this, many studies do not report their methods, results, and discussion in a manner that is conducive to knowledge translation. With several consumer nutritional genomics companies now offering genetic testing for personalized nutrition, proper reporting of nutritional genomics research for knowledge translation is of vital importance. Common reporting errors relate to SNP and genotype reporting, results lacking detail, consideration of linkage disequilibrium, mechanisms of action/functional SNPs, details of dietary intake, and sample reporting. Because of this, knowledge translation professionals may be unable or challenged in their attempt to use the findings from such research to inform clinical practice in nutritional genomics and personalized nutrition. The present article provides an overview of the issues at hand. It further pre-sents a checklist as well as table and figure templates for researchers to use when reporting the results of original research in nutritional genomics to inform knowledge translation.

中文翻译:

加强营养基因组学研究的报告,为个性化营养中的知识翻译提供信息

研究营养遗传相互作用的最终目标是能够为个体提供基因定制的营养建议(当证据充足时),以优化健康结果。因此,原始研究经常讨论结果为基因定制营养建议提供信息的潜力。尽管如此,许多研究并没有以有利于知识翻译的方式报告他们的方法、结果和讨论。随着几家消费者营养基因组学公司现在提供个性化营养的基因测试,正确报告营养基因组学研究以进行知识翻译至关重要。常见的报告错误与 SNP 和基因型报告、结果缺乏细节、连锁不平衡的考虑、作用机制/功能性 SNP、膳食摄入量和样本报告的详细信息。因此,知识翻译专业人员在尝试使用此类研究的结果为营养基因组学和个性化营养的临床实践提供信息时可能无法或面临挑战。本文概述了手头的问题。它还提供了一份清单以及表格和图形模板,供研究人员在报告营养基因组学原始研究结果时使用,以告知知识翻译。
更新日期:2021-01-21
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