Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates. Among these viruses, those belonging to the Ebolavirus genus—particularly Ebola virus, Sudan virus, and Bundibugyo virus—represent some of the most pathogenic to humans. Taï Forest virus (TAFV) is thought to be among the least pathogenic ebolaviruses; however, only a single non-fatal case has been documented in humans, in 1994. With the recent success of the ferret as a lethal model for a number of ebolaviruses, we set out to evaluate its suitability as a model for TAFV. Our results demonstrate that, unlike other ebolaviruses, TAFV infection in ferrets does not result in lethal disease. None of the intramuscularly inoculated animals demonstrated any overt signs of disease, whereas the intranasally inoculated animals exhibited mild to moderate weight loss during the early stage of infection but recovered quickly. Low levels of viral RNA were detected in the blood and tissues of several animals, particularly the intranasally inoculated animals, and all animals mounted a humoral immune response, with high titers of GP-specific IgG detectable as early as 14 days post-infection. These data provide additional insight into the pathogenesis of TAFV.

中文翻译：

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塔伊森林病毒不会在雪貂中引起致命疾病

丝状病毒是人畜共患的负义RNA病毒，大多数能够在人类和非人类灵长类动物中引起严重的疾病，病死率通常很高。在这些病毒中，属于埃博拉病毒的病毒属-特别是埃博拉病毒，苏丹病毒和Bundibugyo病毒-代表对人类最具致病性的一些。Taï森林病毒（TAFV）被认为是致病性最低的埃博拉病毒。但是，在1994年，人类只记录了一个非致命病例。随着雪貂作为许多埃博拉病毒致死模型的最新成功，我们着手评估其作为TAFV模型的适用性。我们的结果表明，与其他埃博拉病毒不同，雪貂中的TAFV感染不会导致致命性疾病。肌肉内接种的动物均未显示任何明显的疾病迹象，而鼻内接种的动物在感染的早期阶段表现出轻度至中度的体重减轻，但恢复很快。在几只动物的血液和组织中检测到低水平的病毒RNA，尤其是鼻内接种的动物，并且所有动物都表现出体液免疫反应，早在感染后14天就可检测到高滴度的GP特异性IgG。这些数据为TAFV的发病机理提供了更多的见解。