In bone regeneration, obtaining a vital bone as similar as possible to native bone is sought. This review aimed to evaluate the efficacy of stem cells in maxillary bone regeneration for implant rehabilitation and to review the different techniques for obtaining and processing these cells. A systematic review and meta-analysis were performed using the Pubmed/Medline (NCBI), Cochrane, Scielo, and Scopus databases, without restriction on the publication date. The following Mesh terms were used, combined by the Boolean operator “AND”: “dental implants” AND “stem cells” AND “bioengineering”. Applying inclusion and exclusion criteria, five articles were obtained and three were added after manual search. The results from the meta-analysis (18 patients) did not provide significant differences despite the percentage of bone formed in the maxillary sinus, favoring the stem cell group, and the analysis of the percentage of residual Bio-Oss^® showed results favoring the control group. Stem cell regeneration usually shows positive vascular and viable bone formation. In conclusion, using mesenchymal stem cells in bone regeneration provides benefits in the quality of bone, similar or even superior to autologous bone, all this through a minimally invasive procedure.

中文翻译：

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间充质干细胞在口腔种植中的骨再生临床疗效。系统评价和荟萃分析

在骨再生中，寻求获得与天然骨尽可能相似的重要骨。这篇综述旨在评估干细胞在上颌骨再生中修复种植体的功效，并综述获得和处理这些细胞的不同技术。使用Pubmed / Medline（NCBI），Cochrane，Scielo和Scopus数据库进行了系统的综述和荟萃分析，而没有发布日期的限制。使用以下网格术语，并由布尔运算符“ AND”组合：“牙科植入物”，“干细胞”和“生物工程”。应用纳入和排除标准，在手动搜索后获得了五篇文章，并添加了三篇文章。荟萃分析的结果（18例患者）没有显着差异，尽管上颌窦中形成骨的百分比较高，^®显示的结果有利于对照组。干细胞再生通常显示出积极的血管和活骨形成。总之，在骨髓再生中使用间充质干细胞可提供有益于骨骼质量的益处，其质量甚至优于自体骨骼，所有这些都是通过微创手术实现的。