Eryptosis is a coordinated, programmed cell death culminating with the disposal of cells without disruption of the cell membrane and the release of endocellular oxidative and pro-inflammatory milieu. While providing a convenient form of death for erythrocytes, dysregulated eryptosis may result in a series of detrimental and harmful pathological consequences highly related to the endothelial dysfunction (ED). Metabolic syndrome (MetS) is described as a cluster of cardiometabolic factors (hyperglycemia, dyslipidemia, hypertension and obesity) that increases the risk of cardiovascular complications such as those related to diabetes and atherosclerosis. In the light of the crucial role exerted by the eryptotic process in the ED, the focus of the present review is to report and discuss the involvement of eryptosis within MetS, where vascular complications are utterly relevant. Current knowledge on the mechanisms leading to eryptosis in MetS-related conditions (hyperglycemia, dyslipidemia, hypertension and obesity) will be analyzed. Moreover, clinical evidence supporting or proposing a role for eryptosis in the ED, associated to MetS cardiovascular complications, will be discussed.

中文翻译：

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代谢综合征中自杀性红细胞死亡

加密是协调的程序性细胞死亡，最终导致细胞处置而不破坏细胞膜以及释放细胞内氧化和促炎性环境。在为红细胞提供方便的死亡形式的同时，失调的加密可能导致一系列与内皮功能障碍（ED）高度相关的有害和有害病理后果。代谢综合症（MetS）被描述为一组心血管代谢因素（高血糖，血脂异常，高血压和肥胖），增加了心血管并发症（如与糖尿病和动脉粥样硬化相关的风险）的风险。鉴于加密过程在ED中所起的关键作用，本综述的重点是报告和讨论加密在MetS中的参与，与血管并发症完全相关的地方。将分析有关与MetS相关的疾病（高血糖，血脂异常，高血压和肥胖）中的加密机制的最新知识。此外，将讨论支持或提出在ED中与MetS心血管并发症相关的加密作用的临床证据。