Gastric motility is coordinated by underlying bioelectrical 'slow wave' activity. Slow wave dysrhythmias are associated with motility disorders, including gastroparesis, offering an under-explored potential therapeutic target. While ablation is widely used to treat cardiac arrhythmias, this approach has not yet been trialed for gastric electrical abnormalities. We hypothesized that ablation can create localized conduction blocks and modulate slow wave activation. Radiofrequency ablation was performed on the porcine serosa in vivo, encompassing a range of parameters (55-85°C, adjacent points forming a line, 5-10 s per point). High-resolution electrical mapping (16×16 electrodes; 6×6 cm) was applied to define baseline and acute post-ablation activation patterns. Tissue damage was evaluated by H&E and c-Kit stains. Results demonstrated that RF ablation successfully induced complete conduction block and a full thickness lesion in the muscle layer at energy doses of 65-75°C for 5-10 s per point. Gastric ablation may hold therapeutic potential for gastric electrical abnormalities in future.

中文翻译：

---

胃消融作为调节体内胃电导的新技术

胃动力由潜在的生物电“慢波”活动协调。慢波心律失常与运动障碍有关，包括胃轻瘫，提供了一个未被充分探索的潜在治疗目标。虽然消融被广泛用于治疗心律失常，但这种方法尚未针对胃电异常进行试验。我们假设消融可以产生局部传导阻滞并调节慢波激活。在体内对猪浆膜进行射频消融，包括一系列参数（55-85°C，相邻点形成一条线，每点 5-10 秒）。应用高分辨率电映射（16×16 电极；6×6 cm）来定义基线和急性消融后激活模式。通过 H&E 和 c-Kit 染色评估组织损伤。结果表明，RF 消融在 65-75°C 的能量剂量下，每点 5-10 秒成功地诱导了肌肉层的完全传导阻滞和全层损伤。胃消融可能在未来对胃电异常具有治疗潜力。