An anonymous user of PubPeer reported the presence of duplicated and horizontally flipped western blot bands in Figure 5C of the article ‘The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90’ https://doi.org/10.1016/j.fob.2014.09.003. This duplication was subsequently confirmed by our image integrity analyst. The β‐actin bands for the cytosol sample at 120 min after β‐NF or DMSO treatment are identical to the β‐actin bands for the cytosol sample at 360 min after β‐NF or DMSO treatment, but are horizontally flipped.

The corresponding author informed the journal that the original data for this manuscript have been discarded, and thus it is no longer possible to investigate this apparent error.

This Editorial Note is intended to alert our readers to the fact that the data for the 120 and 360 min time points in Figure 5C should be treated with caution. However, the translocation of AhR from the cytosol to the nucleus in response to β‐NF treatment can still be observed by comparison of the western blots of samples treated for 0, 15, 30, and 60 min. Therefore, we are satisfied that the key conclusions of the manuscript are not affected by the error in this figure.

PubPeer的一位匿名用户报告了文章“分子伴侣HSP90活化芳烃受体（AhR）的机制”图5C中重复和水平翻转的西方印迹带的存在，网址为https://doi.org/10.1016/j .fob.2014.09.003。我们的图像完整性分析师随后确认了此重复。β-NF或DMSO处理后120分钟时胞浆样品的β-肌动蛋白谱带与β-NF或DMSO处理后360分钟时胞浆样品的β-肌动蛋白谱带相同，但水平翻转。

通讯作者告知该期刊该手稿的原始数据已被丢弃，因此不再可能调查此明显错误。

本编辑说明旨在提醒我们的读者：图5C中120分钟和360分钟时间点的数据应谨慎对待。然而，通过比较处理0、15、30和60分钟的样品的Western印迹，仍然可以观察到响应β-NF处理而使AhR从胞质溶胶转移至细胞核。因此，我们感到满意的是，该手稿的关键结论不受该图中错误的影响。