Identification of key neutral species in atmospheric‐pressure plasma for promoting proliferation of fibroblast cells,Plasma Processes and Polymers

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Identification of key neutral species in atmospheric‐pressure plasma for promoting proliferation of fibroblast cells
Plasma Processes and Polymers ( IF 2.9 ) Pub Date : 2021-01-21 , DOI: 10.1002/ppap.202000225
Yuki Hori ₁ , Naoyuki Iwata _{1,

2} , Vladislav Gamaleev ₃ , Jun‐Seok Oh ₄ , Tomiyasu Murata ₅ , Masaru Hori ₃ , Masafumi Ito ₁

Affiliation

To identify the key neutral species from atmospheric‐pressure plasma for promoting the proliferation of fibroblast cells, an atmospheric‐pressure radical generator was employed. A cell viability assay showed that the proliferation of fibroblasts was significantly promoted through radical treatment, resulting in the highest promotion ratio of 24%. The densities of the neutral radicals supplied by the radical generator were measured via mass spectrometry at atmospheric pressure. To determine an effective factor for the promotion, the dose dependencies of these radicals on the promotion ratio were investigated. The promotion ratio exhibited a strong correlation only with the NO• dose. These results confirmed that NO• is a direct trigger of plasma‐enhanced cell proliferation.

中文翻译：

鉴定大气压血浆中促进成纤维细胞增殖的关键中性物质

为了从大气压力血浆中鉴定促进成纤维细胞增殖的关键中性物质，使用了大气压力自由基发生器。细胞活力分析表明，通过自由基处理可显着促进成纤维细胞的增殖，从而导致最高的增殖率为24％。由自由基产生剂提供的中性自由基的密度是通过质谱在大气压力下测量的。为了确定促进有效的因素，研究了这些自由基对促进比例的剂量依赖性。促进率仅与NO•剂量显示出很强的相关性。这些结果证实了NO•是血浆增强细胞增殖的直接触发因素。

更新日期：2021-01-21

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