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Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2021-01-21 , DOI: 10.1002/jmv.26815
Angelica Rico 1 , Sheila C Dollard 2 , Diana Valencia 3 , Sheryll Corchuelo 1 , Van T Tong 3 , Katherine Laiton-Donato 1 , Minal M Amin 2 , Monica Benavides 4 , Phili Wong 2 , Suzanne Newton 5 , Marcela Daza 4 , Jordan Cates 3 , Maritza Gonzalez 1 , Laura D Zambrano 3 , Marcela M Mercado 1 , Elizabeth C Ailes 3 , Helena M Rodriguez 1 , Suzanne M Gilboa 3 , Jacqueline Acosta 4 , Jessica Ricaldi 3 , Dioselina Pelaez 1 , Margaret A Honein 3 , Martha L Ospina 1 , Tatiana M Lanzieri 2
Affiliation  

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8–12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%–98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%–18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%–59.1%) had postnatal infection.

中文翻译:

哥伦比亚母婴巨细胞病毒感染流行病学

我们评估了哥伦比亚的母婴巨细胞病毒 (CMV) 感染情况。在妊娠 10 周(四分位距:8-12)周(n  = 1501)时检测母体血清中的 CMV 免疫球蛋白 G 抗体。对婴儿尿液进行 CMV DNA 聚合酶链反应以诊断先天性(≤21 天)和产后(>21 天)感染。产妇 CMV 血清阳性率为 98.1%(95% 置信区间 [CI]:97.5%–98.8%)。先天性 CMV 患病率为 8.4(95% CI:3.9%–18.3%;6/711)/1000 名活产。在 472 名未确诊先天性 CMV 感染的婴儿中,随后在 6 个月大时进行了检测,其中 258 名(54.7%,95% CI:50.2%–59.1%)发生了产后感染。
更新日期:2021-01-21
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