当前位置: X-MOL 学术Cytoskeleton › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Physical evidence on desmin–lamin B interaction
Cytoskeleton ( IF 2.4 ) Pub Date : 2021-01-21 , DOI: 10.1002/cm.21651
Ecem Kural-Mangıt 1, 2 , Pervin Rukiye Dinçer 1
Affiliation  

Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co‐immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network.

中文翻译:

desmin-lamin B 相互作用的物理证据

结蛋白是位于细胞质中的肌肉特异性中间丝蛋白。另一方面,Lamin B 是一种核中间丝蛋白。有研究表明 desmin 和 lamin B 之间可能存在相互作用,但没有物理证据。在本研究中,我们首次通过野生型 AB 斑马鱼(Danio rerio,Hamilton)肌肉组织中的相互共免疫沉淀证明了结蛋白和核纤层蛋白 B 之间的物理相互作用。desmin 和 lamin B 之间的相互作用可能是一种新型核质通信网络的先导。
更新日期:2021-02-10
down
wechat
bug