Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co‐immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network.

中文翻译：

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desmin-lamin B 相互作用的物理证据

结蛋白是位于细胞质中的肌肉特异性中间丝蛋白。另一方面，Lamin B 是一种核中间丝蛋白。有研究表明 desmin 和 lamin B 之间可能存在相互作用，但没有物理证据。在本研究中，我们首次通过野生型 AB 斑马鱼（Danio rerio，Hamilton）肌肉组织中的相互共免疫沉淀证明了结蛋白和核纤层蛋白 B 之间的物理相互作用。desmin 和 lamin B 之间的相互作用可能是一种新型核质通信网络的先导。