Dyspepsia, one of the most prevalent diseases of the digestive tract that impacts the quality of patient life, is mainly caused by gastrointestinal motility disorder. Hawthorn is a commonly used traditional Chinese medicine for treating dyspepsia, and has been proven to improve gastrointestinal motility. Herein, a rat model of gastrointestinal motility disorder was established by subcutaneous injection with atropine. The modeled rats were treated with four polar parts (T1–4 in descending polarity, corresponding to water, n‐butanol, ethyl acetate and petroleum ether extracts, respectively) of hawthorn. Through metabolomics analysis, a total of 20 significantly metabolites were identified with significant changes in their abundance levels and these metabolites were related to many metabolic pathways such as amino acid metabolism and primary bile acid biosynthesis. The results showed that T3 had the best therapeutic effect of promoting gastrointestinal motility. Other parts showed no obvious therapeutic effect, demonstrating that the effective components of hawthorn may be compounds of medium polarity. T3 might achieve good therapeutic effects owing to the gastrointestinal motility promotion activity, and by rectifying the disturbed metabolic pathways in the gastrointestinal motility disorder model.

中文翻译：

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基于LC-MS的血浆代谢组学研究山楂不同极性部位对胃肠动力障碍的干预作用

消化不良是影响患者生活质量的最普遍的消化道疾病之一，主要由胃肠蠕动障碍引起。山楂是治疗消化不良的常用中药，并已被证明可改善肠胃蠕动。在此，通过皮下注射阿托品建立了胃肠道动力障碍的大鼠模型。建模的大鼠接受了四个极性部分（T1-4的极性递减，对应于水，n-山楂的丁醇，乙酸乙酯和石油醚提取物。通过代谢组学分析，总共鉴定出20种重要的代谢物，它们的丰度水平发生了显着变化，这些代谢物与许多代谢途径（例如氨基酸代谢和初级胆汁酸生物合成）相关。结果表明，T3具有最佳的促进肠胃蠕动的治疗作用。其他部位没有明显的治疗作用，表明山楂的有效成分可能是中等极性的化合物。T3可能由于肠胃蠕动促进活动并通过纠正肠胃蠕动障碍模型中代谢途径的紊乱而取得了良好的治疗效果。