Abstract

Atmospheric pressure plasma jets generated using noble gases have been the focus of intense investigation for over 2 decades due to their unique physicochemical properties and their suitability for treating living tissues to elicit a controlled biological response. Such devices enable the generation of a non-equilibrium plasma to be spatially separated from its downstream point of application, simultaneously providing inherent safety, stability and reactivity. Underpinning key plasma mediated biological applications are the reactive oxygen and nitrogen species (RONS) created when molecular gases interact with the noble gas plasma, yielding a complex yet highly reactive chemical mixture. The interplay between the plasma physics, fluid dynamics and plasma chemistry ultimately dictates the chemical composition of the RONS arriving at a biological target. This contribution reviews recent developments in understanding of the interplay between the flowing plasma, the quiescent background and a biological target to promote the development of future plasma medical therapies.

Graphical abstract

中文翻译：

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生物医学应用中低温等离子体射流中气相和液相相互作用的综述

摘要

使用稀有气体产生的大气压等离子体射流由于其独特的理化性质以及对治疗活体组织以引起可控的生物反应的适用性，一直是20多年来的研究重点。这样的装置使得非平衡等离子体的产生能够在空间上与其下游应用点分开，同时提供固有的安全性，稳定性和反应性。当分子气体与稀有气体等离子体相互作用时，产生的反应性氧和氮物种（RONS）会支撑关键的等离子体介导的生物应用，从而形成复杂而高反应性的化学混合物。等离子体物理之间的相互作用，流体动力学和等离子体化学最终决定了RONS到达生物靶标的化学组成。该贡献回顾了在了解流动血浆，静态背景和生物学靶标之间的相互作用方面的最新进展，以促进未来血浆药物治疗的发展。

图形概要