The emergence of new viruses is a matter of significant concern in the current decade. It has dazed the indigenous healthcare systems in various parts of the world. Consequently, the resources for fighting the rapid spread of the DENV are ineffectual, insufficient, and incompetent. Several environmental factors have been allied with dengue fever transmission. High documentation of neuropathogenesis in dengue-infected individuals in recent years reflects the significance of our study, and the information discussed in this review can be used to enhance clinical awareness along with advances in diagnostic approaches. The replication of the DENV genome is usually engaged in a membrane-linked replication complex; the virion budding and morphogenesis have been found to take place in the modified endoplasmic reticulum membranes. Most of these non-structural proteins are believed to be responsible for RNA replication and polyprotein processing. The nucleic acid-based strategies have provided high sensitivity and progressively replacing conventional techniques. Advanced technologies like PCR have offered timely serotyping of dengue viruses, which illustrates the early warning of dengue epidemics. The molecular methods help to characterize the key factors responsible for the rapid spread of viruses and thereby update the vector control programmes targeted at extenuating their adverse impacts on public health. The vast diversity of dengue virus strains worldwide with special inference on their clinical manifestations and genetic characteristics was also analyzed in this study. As dengue threatens one third of the world's population, practical applications of advanced molecular strategies from an environmental and phylogenetic perspective are critical for disease control.

中文翻译：

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登革热血清型的环境流行病学和神经学表现以及对分子趋势、病毒检测和致病性的特殊推断

新病毒的出现是近十年来备受关注的问题。它让世界各地的土著医疗保健系统感到​​茫然。因此，用于对抗 DENV 快速传播的资源是无效的、不足的和无能的。几个环境因素与登革热传播有关。近年来对登革热感染者神经发病机制的大量记录反映了我们研究的重要性，本综述中讨论的信息可用于提高临床意识以及诊断方法的进步。DENV 基因组的复制通常参与一个与膜相关的复制复合体；已发现病毒粒子出芽和形态发生发生在修饰的内质网膜中。大多数这些非结构蛋白被认为负责 RNA 复制和多蛋白加工。基于核酸的策略提供了高灵敏度并逐渐取代传统技术。PCR等先进技术提供了登革热病毒的及时血清分型，这说明了登革热流行的早期预警。分子方法有助于表征导致病毒快速传播的关键因素，从而更新旨在减轻其对公共卫生的不利影响的病媒控制计划。本研究还分析了世界范围内登革热病毒株的巨大多样性及其临床表现和遗传特征的特殊推断。由于登革热威胁着世界三分之一的人口，