SPTC is a mix of four herbal components (Salvia officinalis, Panax ginseng, Trigonella foenum-graeceum, and Cinnamomum zeylanicum) which might be prevented the development of AGE rich diet-induced diabetic complication and liver injury through activated the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway. Nrf2, as a master regulator of antioxidant response elements by activating cytoprotective genes expression, is decreased oxidative stress that associated with hyperglycemia and increases insulin sensitivity. the aim of this study was to assess whether the combination therapy of SPTC along with exercise or metformin moderate oxidative stress related liver injurie with more favorable effects in the treatment of AGE rich diet-induced type 2 diabetic mice. We induced diabetes in C57BL/6 mice by AGE using a diet supplementation and limitation of physical activity. After 16 weeks of intervention, AGE fed mice were compared to control mice. Diabetic mice were assigned into seven experimental groups (each group; n = 5): diabetic mice, diabetic mice treated with SPTC (130 mg/kg), diabetic mice treated with Salvia Officinalis (65 mg/kg), diabetic mice treated with metformin (300 mg/kg), diabetic mice with endurance exercise training, diabetic mice treated with SPTC + metformin (130/300 mg/kg), diabetic mice treated with SPTC + exercise training. SPTC + exercise and SPTC + metformin reduced diabetic complications like gain weight, water and calorie intake, blood glucose, insulin, and GLUT4 content more efficiently than each treatment. These combinations improved oxidative stress hemostasis by activating the Nrf2 signaling pathway and attenuating keap1 protein more significantly. Eventually, combined treatment of SPTC with exercise or metformin as a novel approach had more beneficial effects to prevent the development of diabetes and oxidative stress associated with hyperglycemia.

中文翻译：

---

草药化合物 (SPTC) 与运动或二甲双胍的组合通过在富含 AGE 饮食诱导的 2 型糖尿病小鼠中激活 Nrf2-Keap1 轴后下调应激氧化途径，更有效地缓解糖尿病并发症


SPTC 是四种草药成分（丹参、人参、胡芦巴和锡兰肉桂）的混合物，可通过激活核因子 erythroid-2- 来预防富含 AGE 的饮食诱发的糖尿病并发症和肝损伤的发生。相关因子 2 (Nrf2) 途径。 Nrf2 作为抗氧化反应元件的主要调节因子，通过激活细胞保护基因的表达，减少与高血糖相关的氧化应激，并增加胰岛素敏感性。本研究的目的是评估 SPTC 与运动或二甲双胍联合治疗是否能减轻氧化应激相关的肝损伤，并在治疗富含 AGE 饮食诱导的 2 型糖尿病小鼠中具有更有利的效果。我们通过饮食补充和限制体力活动，通过 AGE 诱导 C57BL/6 小鼠患糖尿病。干预 16 周后，将喂食 AGE 的小鼠与对照小鼠进行比较。将糖尿病小鼠分为七个实验组（每组；n = 5）：糖尿病小鼠、用SPTC（130 mg/kg）治疗的糖尿病小鼠、用丹参（65 mg/kg）治疗的糖尿病小鼠、用二甲双胍治疗的糖尿病小鼠(300 mg/kg)，进行耐力运动训练的糖尿病小鼠，用SPTC +二甲双胍治疗的糖尿病小鼠(130/300 mg/kg)，用SPTC +运动训练治疗的糖尿病小鼠。 SPTC + 运动和 SPTC + 二甲双胍比每种治疗更有效地减少了糖尿病并发症，例如体重增加、水和热量摄入、血糖、胰岛素和 GLUT4 含量。这些组合通过激活 Nrf2 信号通路并更显着地减弱 keap1 蛋白来改善氧化应激止血。 最终，SPTC 与运动或二甲双胍联合治疗作为一种新方法，对预防糖尿病和与高血糖相关的氧化应激的发展具有更有益的效果。