Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes through several mechanisms, including immunosuppression; stimulation of angiogenesis; transition to cancer-associated fibroblasts; inhibition of cancer cell apoptosis; induction of epithelial–mesenchymal transition (EMT); and increase metastasis and chemoresistance. However, other studies have shown that MSCs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the AKT and Wnt signaling pathways. In this review, we discuss the supportive and suppressive impacts of MSCs on tumor progression and metastasis. We also discuss MSC-based therapeutic strategies for cancer based on their potential for homing to tumor sites.

中文翻译：

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间充质干细胞作为肿瘤生长的双刃剑：关注间充质干细胞衍生的细胞因子


间充质干细胞（MSC）表现出对肿瘤部位的归巢能力。大量报告表明，它们通过多种机制参与多种肿瘤促进过程，包括免疫抑制；刺激血管生成；转变为癌症相关成纤维细胞；抑制癌细胞凋亡；诱导上皮-间质转化（EMT）；并增加转移和化疗耐药性。然而，其他研究表明，间充质干细胞通过抑制血管生成、增加炎症浸润、细胞凋亡和细胞周期停滞以及抑制 AKT 和 Wnt 信号通路来抑制肿瘤生长。在这篇综述中，我们讨论了间充质干细胞对肿瘤进展和转移的支持和抑制作用。我们还根据间充质干细胞归巢到肿瘤部位的潜力，讨论了基于间充质干细胞的癌症治疗策略。