Advances in gelatin-based hydrogels for wound management,Journal of Materials Chemistry B

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Advances in gelatin-based hydrogels for wound management
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-22 , DOI: 10.1039/d0tb02582h
Jeon Il Kang _{1,

2,

3} , Kyung Min Park _{1,

2,

3,

4,

5}

Affiliation

Skin wounds can be classified into two categories, namely acute and chronic wounds. While acute wounds are healed by the normal wound healing process, chronic wounds are not normally healed, causing inflammation, pain, discomfort, serious complications, and economic burden owing to treatment costs. To alleviate and treat chronic wounds, various biomaterials have been developed. Among them, in situ forming polymeric hydrogels have been widely used as a promising wound care material due to their beneficial properties, including sol–gel phase transition, moisturizing effect on the surrounding environment, biocompatibility, and structural similarity to the native extracellular matrix. The development of bioactive hydrogels that provide artificial cellular microenvironments or stimulate surrounding tissues through physicochemical and biological stimuli is an emerging trend in the fabrication of hydrogels. Notably, gelatin-based hydrogels have attracted much attention as bioactive matrices owing to their biocompatibility, biodegradability, and various functional moieties for chemical modification. In this review, we discuss the development and use of advanced gelatin-based hydrogels for wound management and tissue regeneration.

中文翻译：

用于伤口处理的明胶水凝胶的研究进展

皮肤伤口可分为两类，即急性和慢性伤口。尽管急性伤口可以通过正常的伤口愈合过程治愈，但慢性伤口通常不能治愈，从而由于治疗费用而导致发炎，疼痛，不适，严重的并发症和经济负担。为了减轻和治疗慢性伤口，已经开发了各种生物材料。其中，就地形成聚合物的水凝胶具有有益的特性，包括溶胶-凝胶相变，对周围环境的保湿作用，生物相容性以及与天然细胞外基质的结构相似性，因此被广泛用作有希望的伤口护理材料。通过物理化学和生物刺激提供人工细胞微环境或刺激周围组织的生物活性水凝胶的开发是水凝胶制造中的新兴趋势。明显地，基于明胶的水凝胶由于其生物相容性，生物降解性和用于化学修饰的各种功能部分而作为生物活性基质备受关注。在这篇综述中，我们讨论了用于伤口处理和组织再生的高级明胶水凝胶的开发和使用。

更新日期：2021-01-20

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