Background: The human angiotensin I converting enzyme 1 (ACE1) gene insertion/deletion (I/D) polymorphism is classified based on the presence or absence of a 287 bp Alu sequence. The ACE1 D allele is associated with higher ACE1 concentrations in tissues. Previous research has shown that susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily determined by the affinity between the viral receptor-binding domain and the host human receptor angiotensin-converting enzyme 2 (hACE2) receptor. In the human genome, ACE2 is identified as a homolog to ACE1.

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ACE1 D 等位基因在波斯尼亚-黑塞哥维那人群中的分布及其在 COVID-19 区域流行病学图片中的可能作用

背景：人血管紧张素 I 转换酶 1 ( ACE1)基因插入/缺失 (I/D) 多态性根据 287 bp Alu序列的存在与否进行分类。所述ACE1 d等位基因与较高的相关联ACE1在组织中的浓度。先前的研究表明，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染的易感性主要取决于病毒受体结合域与宿主人受体血管紧张素转换酶 2 (hACE2) 受体之间的亲和力。在人类基因组中， ACE2被鉴定为ACE1的同源物。