Direct Access for the Regio- and Stereoselective Synthesis of N-Alkenylpyrazoles and Chromenopyrazoles,The Journal of Organic Chemistry

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Direct Access for the Regio- and Stereoselective Synthesis of N-Alkenylpyrazoles and Chromenopyrazoles
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2021-01-19 , DOI: 10.1021/acs.joc.0c02421
Siva Hariprasad Kurma ₁ , Balasubramanian Sridhar , China Raju Bhimapaka ₁

Affiliation

A highly regio- and stereoselective method was developed for the preparation of N-alkenylpyrazoles and chromenopyrazoles by the reaction of N-tosylhydrazones and salicyl N-tosylhydrazones with alkynes under neat conditions in the presence of La(OTf)₃. The present study was found to be efficient and convenient for direct access to N-alkenylpyrazoles and chromenopyrazoles through C–C, C–N, and C–O bond forming reactions. Structure assignment of N-alkenylpyrazole compound 5c was confirmed by X-ray analysis.

中文翻译：

N-烯基吡唑和Chromenopyrazole的区域和立体选择性合成的直接途径

开发了一种高度区域选择性和立体选择性的方法，通过在纯净条件下，在La（OTf）₃存在下，N-甲苯磺酰and和水杨基N-甲苯磺酰with与炔烃反应，制备N-烯基吡唑和苯并吡唑。发现本研究对于通过C–C，C–N和C–O键形成反应直接接触N-烯基吡唑和色吡唑是有效而便捷的。通过X射线分析确认了N-烯基吡唑化合物5c的结构归属。

更新日期：2021-02-05

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