Ligand recognition by cell-surface receptors underlies development and immunity in both animals and plants. Modulating receptor signaling is critical for appropriate cellular responses but the mechanisms ensuring this are poorly understood. Here, we show that signaling by plant receptors for pathogen-associated molecular patterns (PAMPs) in immunity and CLAVATA3/EMBRYO SURROUNDING REGION-RELATED peptides (CLEp) in development employ a similar regulatory module. In the absence of ligand, signaling is dampened through association with specific type-2C protein phosphatases (PP2Cs). Upon activation, PAMP and CLEp receptors phosphorylate divergent cytosolic kinases, which, in turn, phosphorylate the phosphatases, thereby promoting their release from the receptor complexes. Our work reveals a regulatory circuit shared between immune and developmental receptor signaling, which may have broader important implications for plant receptor kinase-mediated signaling in general.

中文翻译：

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保守的调节模块调节免疫和发育中的受体激酶信号传导

细胞表面受体对配体的识别是动植物体内发育和免疫力的基础。调节受体信号传导对于适当的细胞反应至关重要，但是确保这种机制的了解却很少。在这里，我们显示了由植物受体为免疫中的病原体相关分子模式（PAMPs）和开发中的CLAVATA3 / EMBRYO环绕区域相关肽（CLEp）的信号采用了类似的调控模块。在没有配体的情况下，信号传导通过与特定的2C型蛋白磷酸酶（PP2Cs）结合而被抑制。激活后，PAMP和CLEp受体会磷酸化不同的胞质激酶，进而使磷酸酶磷酸化，从而促进其从受体复合物中的释放。