SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma,bioRxiv - Immunology

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SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
bioRxiv - Immunology Pub Date : 2021-03-01 , DOI: 10.1101/2021.01.18.427166
Constantinos Kurt Wibmer ₁ , Frances Ayres ₁ , Tandile Hermanus ₁ , Mashudu Madzivhandila ₁ , Prudence Kgagudi ₁ , Brent Oosthuysen ₁ , Bronwen E Lambson _{1,

2} , Tulio de Oliveira ₃ , Marion Vermeulen ₄ , Karin van der Berg _{4,

5} , Theresa Rossouw ₆ , Michael Boswell ₇ , Veronica Ueckermann ₇ , Susan Meiring ₁ , Anne von Gottberg _{1,

8} , Cheryl Cohen _{1,

9} , Lynn Morris _{1,

2} , Jinal N Bhiman _{1,

10} , Penny L Moore _{1,

2}

Affiliation

National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
South African National Blood Service, Weltevreden Park, South Africa.
Division of Clinical Haematology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa.
Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.
Department of Virology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg.

SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.

中文翻译：

SARS-CoV-2 501Y.V2 逃脱了南非 COVID-19 供体血浆的中和

SARS-CoV-2 501Y.V2 (B.1.351) 是一种导致 COVID-19 的新型冠状病毒谱系，在刺突蛋白的两个免疫显性结构域中包含替换。在这里，我们展示了表达 501Y.V2 刺突蛋白的假病毒完全逃脱了三类治疗相关抗体。这种假病毒还表现出从恢复期血浆的中和作用中大量或完全逃脱，但不结合。这些数据突出了重新感染抗原性不同变体的前景，并预示着基于穗的疫苗的功效降低。

更新日期：2021-03-02

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