During the course of cancer treatment, both efficacy and the adverse effects of drugs on patients should be taken into account. Although some public databases and modeling frameworks have been developed through studies on drug response, the negative effects of drugs are always neglected. Furthermore, most of them only considered the ramifications of the drug on the cell line, but the effects on the patient still require a huge amount of work to integrate data from various databases and calculations, especially in relation to precision treatment. In order to address these issues, we developed the DBPOM (http://www.dbpom.net/, a comprehensive database of pharmaco-omics for cancer precision medicine), which explores various drugs' efficacy levels by calculating their potency in reverse, or enhancing cancer-associated gene expression changes. When compared with existing databases, the DBPOM could estimate the effectiveness of a drug on individual patients through the mapping of various cell lines to each person according to their genetic mutation similarities. The DBPOM is an easy-to-use and one-stop database for clinicians and drug researchers to search and analyze the overall effect of a drug or a drug combination on cancer patients as well as the biological functions that they target. We anticipate that DBPOM will become an important resource and analysis platform for drug development, drug mechanism studies and the discovery of new therapies.

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DBPOM：癌症精密医学药理学的综合数据库

在癌症治疗过程中，应同时考虑疗效和药物对患者的不良影响。尽管通过研究药物反应已经开发了一些公共数据库和建模框架，但药物的负面影响始终被忽略。此外，他们中的大多数仅考虑药物对细胞系的影响，但是对患者的影响仍然需要大量工作来整合来自各种数据库和计算的数据，特别是在精确治疗方面。为了解决这些问题，我们开发了DBPOM（http://www.dbpom.net/，这是用于癌症精密医学的药物组学的综合数据库），该数据库通过反向计算各种药物的功效来探索各种药物的疗效水平，或增强与癌症相关的基因表达变化。当与现有数据库进行比较时，DBPOM可以根据他们的基因突变相似性，通过将各种细胞系映射到每个人，来估计药物对个别患者的有效性。DBPOM是一个易于使用的一站式数据库，供临床医生和药物研究人员搜索和分析药物或药物组合对癌症患者的总体作用以及他们所针对的生物学功能。我们期望DBPOM将成为药物开发，药物机制研究和新疗法发现的重要资源和分析平台。DBPOM是一个易于使用的一站式数据库，供临床医生和药物研究人员搜索和分析药物或药物组合对癌症患者的总体作用以及他们所针对的生物学功能。我们预计DBPOM将成为药物开发，药物机制研究和发现新疗法的重要资源和分析平台。DBPOM是一个易于使用的一站式数据库，供临床医生和药物研究人员搜索和分析药物或药物组合对癌症患者的总体作用以及他们所针对的生物学功能。我们期望DBPOM将成为药物开发，药物机制研究和新疗法发现的重要资源和分析平台。