Ischemic stroke has been becoming one of the leading causes resulting in mortality and adult long-term disability worldwide. Post-stroke pneumonia is a common complication in patients with ischemic stroke and always associated with 1-year mortality. Though ambroxol therapy often serves as a supplementary treatment for post-stroke pneumonia in ischemic stroke patients, its effect on functional recovery and potential mechanism after ischemic stroke remain elusive. In the present study, the results indicated that administration of 70 mg/kg and 100 mg/kg enhanced functional recovery by virtue of decreasing infarct volume. The potential mechanism, to some extent, was due to promoting NSCs differentiation into neurons and interfering NSCs differentiation into astrocytes through increasing GCase expression to activate Wnt/β-catenin signaling pathway in penumbra after ischemic stroke, which advanced basic knowledge of ambroxol in regulating NSCs differentiation and provided a feasible therapy for ischemic stroke treatment, even in other brain disorders in clinic.

缺血性中风已成为导致全球范围内的死亡率和成人长期残疾的主要原因之一。中风后肺炎是缺血性中风患者的常见并发症，并总是伴有1年死亡率。尽管氨溴索疗法通常可作为缺血性中风患者中风后肺炎的辅助治疗，但其对缺血性中风后功能恢复和潜在机制的作用仍然难以捉摸。在本研究中，结果表明，通过减少梗塞体积，分别以70 mg / kg和100 mg / kg的剂量给药可增强功能恢复。在某种程度上，潜在的机制