Daptomycin is an important antibiotic for the treatment of infections caused by Staphylococcus aureus. The emergence of daptomycin resistance in S. aureus is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible S. aureus paired isolates using a zebrafish infection model. We showed that the control of DAP-R S. aureus infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R S. aureus and provide crucial insights into the adaptive evolution of this troublesome pathogen.

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耐达托霉素金黄色葡萄球菌感染对宿主抗菌肽的耐药性

达托霉素是一种重要的抗生素，用于治疗金黄色葡萄球菌引起的感染。金黄色葡萄球菌达托霉素抗药性的出现与治疗失败和持续感染相关，临床预后差。在这里，我们使用斑马鱼感染模型调查了宿主对临床衍生，达托霉素抗性（DAP-R）和易感金黄色葡萄球菌配对分离株的先天免疫反应。我们显示，由于对宿主阳离子抗微生物肽的交叉耐药性，体内DAP-R金黄色葡萄球菌感染的控制减弱。这些数据提供了对由DAP-R金黄色葡萄球菌引起的持续感染的机械理解。 并提供对这种麻烦病原体适应性进化的重要见解。