ABSTRACT

Introduction: Liver diseases caused by hepatitis B virus (HBV) are pandemic infectious diseases that seriously endanger human health, conventional diagnosis methods can not meet the requirements in resource-limited areas. The point of acre detection methods can easily resolve those problems. Herein, we review the most recent advances in POC-based hepatitis B detection methods and present some recommendations for future development. It aims to provide ideas for future research.

Areas covered: Epidemiological data on Hepatitis B, conventional diagnostic methods for hepatitis B detection, some latest point of care detection methods for hepatitis B detection and list out the recommendations for future development.

Expert opinion: This manuscript summarized traditional biomarkers of different hepatitis B stages and recent-developed POCT platforms (including microfluidic platforms and lateral-flow strips) and discuss the challenges associated with their use. Some emerging biomarkers that can be used in hepatitis B diagnosis are also listed. This manuscript has certain guiding significance to the development of hepatitis B detection.

摘要

简介： 乙型肝炎病毒（HBV）引起的肝病是严重危害人类健康的大流行性传染病，在资源有限的地区，常规诊断方法已不能满足要求。英亩检测方法可以轻松解决这些问题。在此，我们回顾了基于 POC 的乙型肝炎检测方法的最新进展，并为未来的发展提出了一些建议。它旨在为未来的研究提供思路。

涵盖领域：乙型肝炎的流行病学数据、乙型肝炎检测的常规诊断方法、一些最新的乙型肝炎检测点检测方法，并列出未来发展的建议。

专家意见：本手稿总结了不同乙型肝炎分期的传统生物标志物和最近开发的 POCT 平台（包括微流控平台和侧流条），并讨论了与使用相关的挑战。还列出了一些可用于乙型肝炎诊断的新兴生物标志物。该稿件对乙肝检测的发展具有一定的指导意义。