Enhanced airway hyperresponsiveness in asthmatic children and mice with A(H1N1)pdm09 infection,Immunity, Inflammation and Disease

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Enhanced airway hyperresponsiveness in asthmatic children and mice with A(H1N1)pdm09 infection
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-01-20 , DOI: 10.1002/iid3.406
Taira Ariyoshi ₁ , Junichiro Tezuka _{2,

3} , Hiroki Yasudo ₁ , Yasufumi Sakata ₁ , Tamaki Nakamura ₁ , Takeshi Matsushige ₁ , Hideki Hasegawa ₄ , Noriko Nakajima ₄ , Akira Ainai ₄ , Atsunori Oga ₅ , Hiroshi Itoh ₅ , Komei Shirabe ₆ , Shoichi Toda ₆ , Ryo Atsuta ₇ , Shouichi Ohga _{1,

8} , Shunji Hasegawa ₁

Affiliation

Severe asthma exacerbation is an important comorbidity of the 2009 HIN1 pandemic (A(H1N1)pdm09) in asthmatic patients. However, the mechanisms underlying severe asthma exacerbation remain unknown. In this study, airway hyperresponsiveness (AHR) was measured in pediatric asthma patients infected with A(H1N1)pdm09. We also evaluated AHR in asthmatic mice with A(H1N1)pdm09 infection and those with seasonal influenza for comparison.

中文翻译：

患有 A(H1N1)pdm09 感染的哮喘儿童和小鼠的气道高反应性增强

严重的哮喘发作是 2009 年 HIN1 大流行 (A(H1N1)pdm09) 在哮喘患者中的重要合并症。然而，严重哮喘发作的潜在机制仍然未知。在这项研究中，测量了感染 A(H1N1)pdm09 的儿童哮喘患者的气道高反应性 (AHR)。我们还评估了患有 A（H1N1）pdm09 感染和季节性流感的哮喘小鼠的 AHR 以进行比较。

更新日期：2021-01-20

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