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Extreme Exposure to Filtered Far‐UVC: A Case Study †
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-02-03 , DOI: 10.1111/php.13385 Ewan Eadie 1 , Isla M R Barnard 2 , Sally H Ibbotson 3 , Kenneth Wood 2
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2021-02-03 , DOI: 10.1111/php.13385 Ewan Eadie 1 , Isla M R Barnard 2 , Sally H Ibbotson 3 , Kenneth Wood 2
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Far-UVC devices are being commercially sold as "safe for humans" for the inactivation of SARS-CoV-2, without supporting human safety data. We felt there was a need for rapid proof-of-concept human self-exposure, to inform future controlled research and promote informed discussion. A Fitzpatrick Skin Type II individual exposed their inner forearms to large radiant exposures from a filtered Krypton-Chloride (KrCl) far-UVC system (SafeZoneUVC, Ushio Inc., Tokyo, Japan) with peak emission at 222 nm. No visible skin changes were observed at 1,500 mJcm-2 , whereas skin yellowing that appeared immediately and resolved within 24 hours occurred with a 6,000 mJcm-2 exposure. No erythema was observed at any time point with exposures up to 18,000 mJcm-2 . These results combined with Monte Carlo Radiative Transfer computer modelling suggest that filtering longer ultraviolet wavelengths is critical for the human skin safety of far-UVC devices. This work also contributes to growing arguments for the exploration of exposure limit expansion, which would subsequently enable faster inactivation of viruses.
中文翻译：
极端暴露于过滤后的远紫外线：案例研究 †
Far-UVC 设备在商业上以“对人类安全”的名义出售，用于灭活 SARS-CoV-2，但没有支持人类安全数据。我们认为需要快速验证概念的人类自我暴露，以告知未来的受控研究并促进知情讨论。Fitzpatrick 皮肤类型 II 个体将其前臂内侧暴露于来自过滤的氯化氪 (KrCl) 远紫外线系统 (SafeZoneUVC, Ushio Inc., Tokyo, Japan) 的大量辐射照射下，峰值发射波长为 222 nm。在 1,500 mJcm-2 下没有观察到明显的皮肤变化，而在 6,000 mJcm-2 暴露下会立即出现并在 24 小时内解决的皮肤变黄。在任何时间点均未观察到红斑，曝光量高达 18,000 mJcm-2。这些结果与蒙特卡罗辐射传递计算机模型相结合，表明过滤更长的紫外线波长对于远紫外线设备的人体皮肤安全至关重要。这项工作还有助于探索扩大暴露限度的争论，这将随后能够更快地灭活病毒。
更新日期：2021-02-03
中文翻译：
极端暴露于过滤后的远紫外线：案例研究 †
Far-UVC 设备在商业上以“对人类安全”的名义出售，用于灭活 SARS-CoV-2，但没有支持人类安全数据。我们认为需要快速验证概念的人类自我暴露，以告知未来的受控研究并促进知情讨论。Fitzpatrick 皮肤类型 II 个体将其前臂内侧暴露于来自过滤的氯化氪 (KrCl) 远紫外线系统 (SafeZoneUVC, Ushio Inc., Tokyo, Japan) 的大量辐射照射下，峰值发射波长为 222 nm。在 1,500 mJcm-2 下没有观察到明显的皮肤变化，而在 6,000 mJcm-2 暴露下会立即出现并在 24 小时内解决的皮肤变黄。在任何时间点均未观察到红斑，曝光量高达 18,000 mJcm-2。这些结果与蒙特卡罗辐射传递计算机模型相结合，表明过滤更长的紫外线波长对于远紫外线设备的人体皮肤安全至关重要。这项工作还有助于探索扩大暴露限度的争论，这将随后能够更快地灭活病毒。
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